Evidence map›Paper›PMID 31447858›Full record

ArticleFrontiers in immunology2019

Cell-Laden Hydrogel as a Clinical-Relevant 3D Model for Analyzing Neuroblastoma Growth, Immunophenotype, and Susceptibility to Therapies.

Alessandra Marrella, Alessandra Dondero, Maurizio Aiello, Beatrice Casu, Daniel Olive, Stefano Regis, Cristina Bottino, Daniela Pende, Raffaella Meazza, Guido Caluori and 2 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

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  5. Mechanical models and measurement methods of solid stress in tumors.Applied microbiology and biotechnology · 2024
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  14. Frontiers in immunology · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alessandra MarrellaCNR-IEIIT Institute, National Research Council of Italy, Genoa, Italy.
Alessandra DonderoDepartment of Experimental Medicine, University of Genoa, Genoa, Italy.
Maurizio AielloReact4life S.r.l., Genoa, Italy.
Beatrice CasuDepartment of Experimental Medicine, University of Genoa, Genoa, Italy.
Daniel OliveTumor Immunology Team, IBISA Immunomonitoring Platform, Cancer Research Center of Marseille, INSERM U1068, CNRS U7258, Institut Paoli-Calmettes, Aix-Marseille University, Marseille, France.
Stefano RegisLaboratory of Clinical and Experimental Immunology, IRCCS Giannina Gaslini, Genoa, Italy.
Cristina BottinoDepartment of Experimental Medicine, University of Genoa, Genoa, Italy.
Daniela PendeLaboratorio di Immunologia, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Raffaella MeazzaLaboratorio di Immunologia, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Guido CaluoriFNUSA-ICRC, Interventional Cardiac Electrophysiology, Brno, Czechia.
Roberta CastriconiDepartment of Experimental Medicine, University of Genoa, Genoa, Italy.
Silvia ScaglioneCNR-IEIIT Institute, National Research Council of Italy, Genoa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High risk Neuroblastoma (NB) includes aggressive, metastatic solid tumors of childhood. The survival rate improved only modestly, despite the use of combination therapies including novel immunotherapies based on the antibody-mediated targeting of tumor-associated surface ligands. Treatment failures may be due to the lack of adequate

Indexed as

HydrogelsNeuroblastomaAlginatesAntineoplastic AgentsCell Line, TumorCell ProliferationHumansImatinib MesylateImmunophenotypingKiller Cells, NaturalModels, BiologicalAlginatesAntineoplastic AgentsHydrogelsImatinib Mesylate3D cancer modelB7-H3 and IFN-γimmunotherapyKIRS/HLA-IneuroblastomaNK cellsPD-LsPVR

Identifiers

PMID31447858
PMCPMC6697063

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.