Evidence map›Paper›PMID 31447828›Full record

ArticleFrontiers in immunology2019

Three Novel Players: PTK2B, SYK, and TNFRSF21 Were Identified to Be Involved in the Regulation of Bovine Mastitis Susceptibility via GWAS and Post-transcriptional Analysis.

Fan Yang, Fanghui Chen, Lili Li, Li Yan, Tarig Badri, Chenglong Lv, Daolun Yu, Manling Zhang, Xiaojun Jang, Jie Li and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Genomic insights into the recent evolution and biodiversity of Italian sheep breeds.Mammalian genome : official journal of the International Mammalian Genome Society · 2025
    Article
  3. Pathogens (Basel, Switzerland) · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Fan YangAnhui Provincial Key Lab of the Conservation and Exploitation of Biological Resources, College of Life Sciences, Anhui Normal University, Wuhu, China.
Fanghui ChenCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China.
Lili LiNational Animal Husbandry Station, Beijing, China.
Li YanDepartment of Radiation Oncology, Linyi People Hospital, Linyi, China.
Tarig BadriCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China.
Chenglong LvCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China.
Daolun YuAnhui Provincial Key Lab of the Conservation and Exploitation of Biological Resources, College of Life Sciences, Anhui Normal University, Wuhu, China.
Manling ZhangAnhui Provincial Key Lab of the Conservation and Exploitation of Biological Resources, College of Life Sciences, Anhui Normal University, Wuhu, China.
Xiaojun JangAnhui Provincial Key Lab of the Conservation and Exploitation of Biological Resources, College of Life Sciences, Anhui Normal University, Wuhu, China.
Jie LiAnhui Provincial Key Lab of the Conservation and Exploitation of Biological Resources, College of Life Sciences, Anhui Normal University, Wuhu, China.
Lu YuanAnhui Provincial Key Lab of the Conservation and Exploitation of Biological Resources, College of Life Sciences, Anhui Normal University, Wuhu, China.
Genlin WangCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China.
Honglin LiDepartment of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, GA, United States.
Jun LiAnhui Provincial Key Lab of the Conservation and Exploitation of Biological Resources, College of Life Sciences, Anhui Normal University, Wuhu, China.
Yafei CaiCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China.
Nanjing Agricultural University · CNAnhui Normal University · CNAugusta University · USLinyi People's Hospital · CNNational Animal Husbandry Service · CN

Funding

Essential role of the Ufm1 E3 ligase in intestinal homeostasisR01DK113409 · NIDDK · AUGUSTA UNIVERSITY · PI LI, HONGLIN · 2017 to 2020
$1.4M
NIDDK NIH HHS R01 DK113409
6 · The paper itself

Abstract

Bovine mastitis is a common inflammatory disease caused by multiple factors in early lactation or dry period. Genome wide association studies (GWAS) can provide a convenient and effective strategy for understanding the biological basis of mastitis and better prevention. 2b-RADseq is a high-throughput sequencing technique that offers a powerful method for genome-wide genetic marker development and genotyping. In this study, single nucleotide polymorphisms (SNPs) of the immune-regulated gene correlative with mastitis were screened and identified by two stage association analysis via GWAS-2b-RADseq in Chinese Holstein cows. We have screened 10,058 high quality SNPs from 7,957,920 tags and calculated their allele frequencies. Twenty-seven significant SNPs were co-labeled in two GWAS analysis models [Bayesian (

Indexed as

Genome-Wide Association StudyPolymorphism, Single NucleotideAnimalsCattleFemaleFocal Adhesion Kinase 2Genetic Predisposition to DiseaseMastitis, BovineReceptors, Tumor Necrosis FactorSyk KinaseFocal Adhesion Kinase 2Receptors, Tumor Necrosis FactorSyk Kinasebovine mastitisimmune responsesprotein tyrosine kinase 2 (PTK2B)SNPsspleen tyrosine kinase (SYK)TNF receptor superfamily member 21 (TNFRSF21)

Identifiers

PMID31447828
PMCPMC6691815
OpenAlexW2966393228

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.