Evidence map›Paper›PMID 31447783›Full record

ArticleFrontiers in endocrinology2019

Sex Dependent Dysregulation of Hepatic Glucose Production in Lean Type 2 Diabetic Rats.

Chellakkan S Blesson, Amy Schutt, Shaji Chacko, Juan C Marini, Pretty Rose Mathew, Daren Tanchico, Meena Balakrishnan, Chandra Yallampalli

Abstract read
In one paragraph

Article in Frontiers in endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Liver adrenoceptor alpha-1b plays a key role in energy and glucose homeostasis in female mice.American journal of physiology. Endocrinology and metabolism · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chellakkan S BlessonDivision for Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Baylor College of Medicine and Family Fertility Center, Texas Childrens' Hospital, Houston, TX, United States.
Amy SchuttDivision for Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Baylor College of Medicine and Family Fertility Center, Texas Childrens' Hospital, Houston, TX, United States.
Shaji ChackoDepartment of Pediatrics, Baylor College of Medicine, Children's Nutritional Research Center, Houston, TX, United States.
Juan C MariniDepartment of Pediatrics, Baylor College of Medicine, Children's Nutritional Research Center, Houston, TX, United States.
Pretty Rose MathewBasic Sciences Perinatology Research Laboratories, Department of Obstetrics and Gynecology, Houston, TX, United States.
Daren TanchicoBasic Sciences Perinatology Research Laboratories, Department of Obstetrics and Gynecology, Houston, TX, United States.
Meena BalakrishnanBasic Sciences Perinatology Research Laboratories, Department of Obstetrics and Gynecology, Houston, TX, United States.
Chandra YallampalliBasic Sciences Perinatology Research Laboratories, Department of Obstetrics and Gynecology, Houston, TX, United States.

Funding

SEX STEROID HORMONES AND CALCITONIN GENE RELATED PEPTIDER01HL058144 · NHLBI · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI CHAUHAN, MADHU LATA S., YALLAMPALLI, CHANDRASEKHAR · 1998 to 2022
$6.9M
Molecular and Vascular MRI of Placenta AccretaR01HD094347 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI ANNAPRAGADA, ANANTH V, FOX, KARIN ANNELIESE · 2018 to 2022
$2.2M
Mechanisms for Sex Differences in Metabolic ProgrammingR01DK114689 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI BLESSON, CHELLAKKAN SELVANESAN, YALLAMPALLI, CHANDRASEKHAR · 2018 to 2021
$1.6M
Developmental programming: influence of sex steroids and mechanismsR01HL102866 · NHLBI · UNIVERSITY OF TEXAS MED BR GALVESTON · PI YALLAMPALLI, CHANDRASEKHAR · 2011 to 2014
$1.5M
NHLBI NIH HHS R01 HL058144NHLBI NIH HHS R01 HL102866NICHD NIH HHS R01 HD094347NIDDK NIH HHS R01 DK114689
6 · The paper itself

Abstract

We have characterized a lean type 2 diabetic rat model by gestational low protein programming. We aimed to identify if the regulation of hepatic glucose production (HGP) via gluconeogenesis and glycogenolysis is affected and if there are any sex differences. Fasting (6-7 months old) type 2 diabetic rats received

Indexed as

developmental programinggluconeogenesisglucose intoleranceglucose productionglycogenolysisinsulin resistance

Identifiers

PMID31447783
PMCPMC6691354

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.