Evidence map›Paper›PMID 31447643›Full record

ReviewFrontiers in neuroscience2019

Current Directions in the Auricular Vagus Nerve Stimulation I - A Physiological Perspective.

Eugenijus Kaniusas, Stefan Kampusch, Marc Tittgemeyer, Fivos Panetsos, Raquel Fernandez Gines, Michele Papa, Attila Kiss, Bruno Podesser, Antonino Mario Cassara, Emmeric Tanghe and 11 more

5 registry-linked trialsOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 175 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
175citing papers in PubMed, 9 pooled it
14.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04379037 nacompletednot on this mapstarted 2020, after this paper: background citation

Vagus Nerve Stimulation ARDS Prevention Trial for COVID-19 Hospitalized Patients

TypeinterventionalSponsorNemechek TechnologiesRan2020 to 2020Enrolled50ConditionsSevere Acute Respiratory Syndrome Coronavirus 2ArmsTranscutaneous Auricular Vagus Nerve Stimulation
NCT05500716 nacompletednot on this mapstarted 2022, after this paper: background citation

The Effect of Application of Vagus Nerve Stimulation on the Treatment Efficiency in Temporomandibular Joint Dysfunction Caused by Myofascial Pain Syndrome

TypeinterventionalSponsorAlper PercinRan2022 to 2023Enrolled50ConditionsTemporomandibular Joint Dysfunction Syndrome, Autonomic Nervous System ImbalanceArmsAuricular Non-Invazive Vagus Nerve Stimulation + Traditional Rehabilitation Program for TMD, Traditional Rehabilitation Program
NCT06782360 nacompletednot on this mapstarted 2025, after this paper: background citation

CAMSAN: Cognitive Augmentation Via Multimodal Sensing and Auricular Neurostimulation

TypeinterventionalSponsorOpenBCIRan2025 to 2026Enrolled45ConditionsHealthy, Cognitive Change, Effects of External Neurostimulation on CognitionArmsActive Neurostimulation, Sham Stimulation
NCT06912399 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Effect of Transauricular Vagus Nerve Stimulation on Postoperative Pain Management in Video Assisted Thoracic Surgery: a Randomized Controlled Clinical Trial

TypeinterventionalSponsorPeking Union Medical College HospitalRan2025 to 2026Enrolled116ConditionsPostoperative Pain, Acute, VATSArmsTransauricular Vagus Nerve Stimulation, Sham Transauricular Vagus Nerve stimulation
NCT06957912 narecruitingnot on this mapstarted 2025, after this paper: background citation

Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Quality of Recovery After Major Noncardiac Surgery: A Randomized Trial.

TypeinterventionalSponsorPeking University First HospitalRan2025 to 2026Enrolled320ConditionsVagus Nerve Stimulation, Transcutaneous Electric Nerve Stimulation, Noncardiac Surgery, Quality of RecoveryArmsTranscutaneous auricular vagus nerve stimulation, Sham stimulation
3 · Its place in the literature

Who cites it

175 citing papers in PubMed, 9 syntheses or guidelines pooled it, 305 citations in OpenAlex.

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115 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 12 institutions in 9 countries.

Eugenijus KaniusasInstitute of Electrodynamics, Microwave and Circuit Engineering, Vienna University of Technology, Vienna, Austria.
Stefan KampuschInstitute of Electrodynamics, Microwave and Circuit Engineering, Vienna University of Technology, Vienna, Austria.
Marc TittgemeyerMax Planck Institute for Metabolism Research, Cologne, Germany.
Fivos PanetsosNeurocomputing and Neurorobotics Research Group, Complutense University of Madrid, Madrid, Spain.
Raquel Fernandez GinesNeurocomputing and Neurorobotics Research Group, Complutense University of Madrid, Madrid, Spain.
Michele PapaLaboratory of Neuronal Networks, Department of Mental and Physical Health and Preventive Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
Attila KissLudwig Boltzmann Cluster for Cardiovascular Research at the Center for Biomedical Research, Medical University of Vienna, Vienna, Austria.
Bruno PodesserLudwig Boltzmann Cluster for Cardiovascular Research at the Center for Biomedical Research, Medical University of Vienna, Vienna, Austria.
Antonino Mario CassaraFoundation for Research on Information Technologies in Society, Zurich, Switzerland.
Emmeric TangheDepartment of Information Technology, Ghent University/IMEC, Ghent, Belgium.
Amine Mohammed SamoudiDepartment of Information Technology, Ghent University/IMEC, Ghent, Belgium.
Thomas TarnaudDepartment of Information Technology, Ghent University/IMEC, Ghent, Belgium.
Wout JosephDepartment of Information Technology, Ghent University/IMEC, Ghent, Belgium.
Vaidotas MarozasBiomedical Engineering Institute, Kaunas University of Technology, Kaunas, Lithuania.
Arunas LukoseviciusBiomedical Engineering Institute, Kaunas University of Technology, Kaunas, Lithuania.
Niko IštukFaculty of Electrical Engineering, Mechanical Engineering and Naval Architecture, University of Split, Split, Croatia.
Antonio ŠarolićFaculty of Electrical Engineering, Mechanical Engineering and Naval Architecture, University of Split, Split, Croatia.
Sarah LechnerSzeleSTIM GmbH, Vienna, Austria.
Wlodzimierz KlonowskiNalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland.
Giedrius VaroneckasSleep Medicine Centre, Klaipeda University Hospital, Klaipëda, Lithuania.
Jozsef Constantin SzélesDepartment for Surgery, Medical University of Vienna, Vienna, Austria.
Ghent University · BEKaunas University of Technology · LTMedical University of Vienna · ATTU Wien · ATUniversidad Complutense de Madrid · ESUniversity of Split · HRFoundation for Research on Information Technologies in Society · CHKlaipėda University · LTLudwig Boltzmann Cluster for Cardiovascular Research · ATMax Planck Institute for Metabolism Research · DEPolish Academy of Sciences · PLUniversity of Campania "Luigi Vanvitelli" · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Electrical stimulation of the auricular vagus nerve (aVNS) is an emerging technology in the field of bioelectronic medicine with applications in therapy. Modulation of the afferent vagus nerve affects a large number of physiological processes and bodily states associated with information transfer between the brain and body. These include disease mitigating effects and sustainable therapeutic applications ranging from chronic pain diseases, neurodegenerative and metabolic ailments to inflammatory and cardiovascular diseases. Given the current evidence from experimental research in animal and clinical studies we discuss basic aVNS mechanisms and their potential clinical effects. Collectively, we provide a focused review on the physiological role of the vagus nerve and formulate a biology-driven rationale for aVNS. For the first time, two international workshops on aVNS have been held in Warsaw and Vienna in 2017 within the framework of EU COST Action "European network for innovative uses of EMFs in biomedical applications (BM1309)." Both workshops focused critically on the driving physiological mechanisms of aVNS, its experimental and clinical studies in animals and humans,

Indexed as

animal researchauricular vagus nervebiophysicsbrain plasticityclinical studiesinflammationnerve stimulation

Identifiers

PMID31447643
PMCPMC6697069
OpenAlexW2964477120

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.