Evidence map›Paper›PMID 31446567›Full record

ArticleDrug safety2019

Recommendations for the Use of Social Media in Pharmacovigilance: Lessons from IMI WEB-RADR.

John van Stekelenborg, Johan Ellenius, Simon Maskell, Tomas Bergvall, Ola Caster, Nabarun Dasgupta, Juergen Dietrich, Sara Gama, David Lewis, Victoria Newbould and 8 more

Abstract read
In one paragraph

Article in Drug safety, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

  1. Review
  2. Article
  3. Understanding social media discourse on antidepressants: unsupervised and sentiment analysis using X.European psychiatry : the journal of the Association of European Psychiatrists · 2025
    Article
  4. Article
  5. Pharmacovigilance in the digital age: gaining insight from social media data.Experimental biology and medicine (Maywood, N.J.) · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

John van StekelenborgJanssen R&D, Horsham, PA, USA. JVanstek@its.jnj.com.ORCID http://orcid.org/0000-0002-5352-3281
Johan ElleniusUppsala Monitoring Centre, Uppsala, Sweden.
Simon MaskellDepartment of Electrical Engineering and Electronics, University of Liverpool, Liverpool, L69 3GJ, UK.
Tomas BergvallUppsala Monitoring Centre, Uppsala, Sweden.
Ola CasterUppsala Monitoring Centre, Uppsala, Sweden.
Nabarun DasguptaGillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Juergen DietrichPharmacovigilance, Bayer AG, Berlin, Germany.
Sara GamaChief Medical Office and Patient Safety, Novartis Global Drug Development, Novartis Pharma Basel, Basel, Switzerland.
David LewisChief Medical Office and Patient Safety, Novartis Global Drug Development, Novartis Pharma Basel, Basel, Switzerland.
Victoria NewbouldPharmacovigilance Department, Inspections and Human Medicines Pharmacovigilance Division, European Medicines Agency (EMA), Amsterdam, The Netherlands.
Sabine BroschPharmacovigilance Department, Inspections and Human Medicines Pharmacovigilance Division, European Medicines Agency (EMA), Amsterdam, The Netherlands.
Carrie E PierceBooz Allen Hamilton (formerly Epidemico, Inc.), Boston, MA, USA.
Gregory PowellGlaxoSmithKline, Global Clinical Safety and Pharmacovigilance, RTP, Research Triangle Park, NC, 27709, USA.
Alicia Ptaszyńska-NeophytouVigilance, Intelligence and Research Group, Medicines and Healthcare products Regulatory Agency (MHRA), 10 South Colonnade, Canary Wharf, London, E14 4PU, UK.
Antoni F Z WiśniewskiAstraZeneca, Patient Safety, Office of the Chief Medical Officer, Cambridge, UK, Granta Park, Cambridge, CB21 6GH, UK.
Phil TregunnoVigilance, Intelligence and Research Group, Medicines and Healthcare products Regulatory Agency (MHRA), 10 South Colonnade, Canary Wharf, London, E14 4PU, UK.
G Niklas NorénUppsala Monitoring Centre, Uppsala, Sweden.
Munir PirmohamedDepartment of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, L69 3GL, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over a period of 3 years, the European Union's Innovative Medicines Initiative WEB-RADR project has explored the value of social media (i.e., information exchanged through the internet, typically via online social networks) for identifying adverse events as well as for safety signal detection. Many patients and clinicians have taken to social media to discuss their positive and negative experiences of medications, creating a source of publicly available information that has the potential to provide insights into medicinal product safety concerns. The WEB-RADR project has developed a collaborative English language workspace for visualising and analysing social media data for a number of medicinal products. Further, novel text and data mining methods for social media analysis have been developed and evaluated. From this original research, several recommendations are presented with supporting rationale and consideration of the limitations. Recommendations for further research that extend beyond the scope of the current project are also presented.

Indexed as

PharmacovigilanceSocial MediaAdverse Drug Reaction Reporting SystemsAlgorithmsDrug-Related Side Effects and Adverse ReactionsEuropean UnionHumansInternet

Identifiers

PMID31446567
PMCPMC6858385

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.