Evidence map›Paper›PMID 31446560›Full record

ArticleCellular and molecular neurobiology2020

Glioprotective Effect of Chitosan-Coated Rosmarinic Acid Nanoemulsions Against Lipopolysaccharide-Induced Inflammation and Oxidative Stress in Rat Astrocyte Primary Cultures.

Flávia Nathiely Silveira Fachel, Morgana Dal Prá, Juliana Hofstätter Azambuja, Marcelo Endres, Valquíria Linck Bassani, Letícia Scherer Koester, Amelia Teresinha Henriques, Alethea Gatto Barschak, Helder Ferreira Teixeira, Elizandra Braganhol

Open access · greenAbstract read
In one paragraph

Article in Cellular and molecular neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Flávia Nathiely Silveira FachelPrograma de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. flavia_fachel@hotmail.com.ORCID http://orcid.org/0000-0002-0777-9497
Morgana Dal PráPrograma de Pós-Graduação em Biociências, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil.
Juliana Hofstätter AzambujaPrograma de Pós-Graduação em Biociências, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil.
Marcelo EndresPrograma de Pós-Graduação em Patologia, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil.
Valquíria Linck BassaniPrograma de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Letícia Scherer KoesterPrograma de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Amelia Teresinha HenriquesPrograma de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Alethea Gatto BarschakPrograma de Pós-Graduação em Patologia, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil.
Helder Ferreira TeixeiraPrograma de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Elizandra BraganholPrograma de Pós-Graduação em Biociências, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil.
Universidade Federal de Ciências da Saúde de Porto Alegre · BRUniversidade Federal do Rio Grande do Sul · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 142202/2018-5Conselho Nacional de Desenvolvimento Científico e Tecnológico 310846/2014-5Conselho Nacional de Desenvolvimento Científico e Tecnológico 422298/2016-6Conselho Nacional de Desenvolvimento Científico e Tecnológico 459619/2014-4Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil Finance Code 001Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul 16/2551-0000265-7Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul 16/2551-0000473-0Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul 17/2551-0001273-9
6 · The paper itself

Abstract

Rosmarinic acid (RA) is a natural polyphenolic compound with a well-documented neuroprotective effect mainly associated with its anti-inflammatory and antioxidant activities. Recently, our research group developed and optimized chitosan-coated RA nanoemulsions (RA CNE) intended to be used for nasal delivery as a new potential neuroprotective therapy. In this sense, the present study aimed to evaluate the protective and/or therapeutic potential of RA CNE in inflammation/oxidative stress induced by LPS (1 μg mL

Indexed as

AnimalsAnimals, NewbornAnti-Inflammatory AgentsAntioxidantsAstrocytesCell MovementCell ProliferationCells, CulturedCell SurvivalChitosanCinnamatesDepsidesEmulsionsGlial Fibrillary Acidic ProteinInflammationLipopolysaccharidesAnti-Inflammatory AgentsAntioxidantsChitosanCinnamatesDepsidesEmulsionsGlial Fibrillary Acidic ProteinLipopolysaccharidesNeuroprotective AgentsRosmarinic AcidAstrocytesChitosan-coated nanoemulsionsGlioprotective effectLipopolysaccharideRosmarinic acid

Identifiers

PMID31446560
PMCPMC11449031
OpenAlexW2969542925

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.