ArticleJournal of natural medicines2020
Sedative effects of the essential oil from the leaves of Lantana camara occurring in the Republic of Benin via inhalation in mice.
Article in Journal of natural medicines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Systematic review of animal studies on the use of herbal medicine for attention-deficit/hyperactivity disorder.Frontiers in psychiatry · 2026Pooled it
- Antiepileptic and Neuroprotective Biochemical Actions of Sabinene Prevent the Development of Pentylenetetrazol-Induced Seizures and Neuropsychiatric Comorbidities in Mice.Journal of molecular neuroscience : MN · 2025Article
- From an Invasive Weed to an Insecticidal Agent: Exploring the Potential ofInternational journal of molecular sciences · 2024Review
- Local knowledge, practices, challenges of ethnopharmacologically used medicinal plants in Benin and implications for brain illnesses.Scientific reports · 2023Article
- Evaluation of the susceptibility of Tritrichomonas foetus to extracts of Lantana camara (Verbenaceae) by flow cytometry.Veterinary research communications · 2023Article
- Modelling Autism Spectrum Disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD) Using Mice and Zebrafish.International journal of molecular sciences · 2022Review
- Lantana camara L. essential oil mediated nano-emulsion formulation for biocontrol application: anti-mosquitocidal, anti-microbial and antioxidant assay.Archives of microbiology · 2022Article
- Aromas Influencing the GABAergic System.Molecules (Basel, Switzerland) · 2022Review
- Factors affecting 2-(2-phenylethyl)chromones in artificial agarwood.Journal of natural medicines · 2022Article
- Essential oils from Melia azedarach L. (Meliaceae) leaves: chemical variability upon environmental factors.Journal of natural medicines · 2022Article
- Activity of Selected Group of Monoterpenes in Alzheimer's Disease Symptoms in Experimental Model Studies-A Non-Systematic Review.International journal of molecular sciences · 2021Review
- Essential Oil from the Leaves ofPharmaceuticals (Basel, Switzerland) · 2021Article
- Sedative effects of inhaled Perilla frutescens essential oils on mice.Journal of natural medicines · 2021Article
- Phytochemical and Safety Evaluations ofToxics · 2021Article
- Sedative effects of l-menthol, d-camphor, phenylethyl alcohol, and geraniol.Journal of natural medicines · 2021Article
- Composition, Seasonal Variation, and Biological Activities ofMolecules (Basel, Switzerland) · 2020Article
- Inhalation Administration of the Bicyclic Ethers 1,8- and 1,4-cineole Prevent Anxiety and Depressive-Like Behaviours in Mice.Molecules (Basel, Switzerland) · 2020Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lantana camara Linn. (Verbenaceae) is used traditionally for its numerous medicinal properties such as antimalarial, antibacterial, anticancer and anti-inflammatory. In the present study, we investigated the chemical composition of essential oil from the leaves of L. camara (LCEO) occurring in the Republic of Benin (West Africa) in comparison with LCEOs from other regions; evaluated its sedative effects in mice via inhalation administration; and identified the compounds responsible for activity. LCEO was extracted by hydrodistillation and chemical analyses of the oil were performed by GC and GC/MS. The oil was dominated by monoterpene hydrocarbons (60.58%) and oxygenated monoterpenes (33.39%), among which sabinene (38.81%) and 1,8-cineole (28.90%) were the most abundant. LCEO administered via inhalation to mice significantly decreased locomotor activity in a dose-dependent manner, mainly at the doses of 0.0004 and 0.04 mg per 400 μL of triethyl citrate (TEC). The oil was fractionated to give two fractions, which were further investigated, and revealed that both sabinene and 1,8-cineole were the principal active compounds. The results of the present study indicated that via inhalation administration, LCEO and its main constituents could be considered as promising candidates for the management of dementia, insomnia, attention deficit hyperactivity disorder and other central nervous system-associated diseases.
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