GuidelineEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2019
Measuring and reporting of vertebral endplate bone marrow lesions as seen on MRI (Modic changes): recommendations from the ISSLS Degenerative Spinal Phenotypes Group.
Guideline in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 42 citations in OpenAlex.
- Oedema on STIR modified the effect of amoxicillin as treatment for chronic low back pain with Modic changes-subgroup analysis of a randomized trial.European radiology · 2021Trial
- Article
- Artificial Intelligence in Spine Neuroimaging: Diagnostic and Prognostic Utility of Novel Biomarkers in Lower Back Pain.Journal of clinical medicine · 2026Review
- The Clinical Significance of the Modic Changes Grading Score.Global spine journal · 2024Article
- Efficacy of stepped care treatment for chronic discogenic low back pain patients with Modic I and II changes.Interventional pain medicine · 2023Article
- Cartilaginous endplates: A comprehensive review on a neglected structure in intervertebral disc research.JOR spine · 2023Review
- Coexistence of Vertebral and Intervertebral Disc Changes in Low Back Pain Patients-In Depth Characterization with Same Day MRI and CT Discography.Diagnostics (Basel, Switzerland) · 2023Article
- Magnetic Resonance Imaging of the Lumbar Spine: Recommendations for Acquisition and Image Evaluation from the BACPAC Spine Imaging Working Group.Pain medicine (Malden, Mass.) · 2023Article
- Implementation of GAN-Based, Synthetic T2-Weighted Fat Saturated Images in the Routine Radiological Workflow Improves Spinal Pathology Detection.Diagnostics (Basel, Switzerland) · 2023Article
- The association of modic changes and chronic low back pain: A systematic review.Journal of orthopaedics · 2023Review
- Paraspinal Muscle in Chronic Low Back Pain: Comparison Between Standard Parameters and Chemical Shift Encoding-Based Water-Fat MRI.Journal of magnetic resonance imaging : JMRI · 2022Article
- The interrater reliability of the novel Udby classification of Modic Changes: A first estimate.Interventional pain medicine · 2022Article
- Editorial on Special Issue "Spine Imaging: Novel Image Acquisition Techniques and Analysis Tools".Diagnostics (Basel, Switzerland) · 2022Article
- Automatic detection and voxel-wise mapping of lumbar spine Modic changes with deep learning.JOR spine · 2022Article
- Multi-scanner and multi-modal lumbar vertebral body and intervertebral disc segmentation database.Scientific data · 2022Article
- Correlation between gene expression and MRI STIR signals in patients with chronic low back pain and Modic changes indicates immune involvement.Scientific reports · 2022Article
- Proton Density Fat Fraction Spine MRI for Differentiation of Erosive Vertebral Endplate Degeneration and Infectious Spondylitis.Diagnostics (Basel, Switzerland) · 2021Article
- Measurement of vertebral endplate bone marrow lesion (Modic change) composition with water-fat MRI and relationship to patient-reported outcome measures.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2021Article
- Article
- Comparison of lumbar degenerative disc disease using conventional fast spin echoThe British journal of radiology · 2021Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
purposeThe positive association between low back pain and MRI evidence of vertebral endplate bone marrow lesions, often called Modic changes (MC), offers the exciting prospect of diagnosing a specific phenotype of chronic low back pain (LBP). However, imprecision in the reporting of MC has introduced substantial challenges, as variations in both imaging equipment and scanning parameters can impact conspicuity of MC. This review discusses key methodological factors that impact MC classification and recommends guidelines for more consistent MC reporting that will allow for better integration of research into this LBP phenotype.
methodsNon-systematic literature review.
resultsThe high diagnostic specificity of MC classification for a painful level contributes to the significant association observed between MC and LBP, whereas low and variable sensitivity underlies the between- and within-study variability in observed associations. Poor sensitivity may be owing to the presence of other pain generators, to the limited MRI resolution, and to the imperfect reliability of MC classification, which lowers diagnostic sensitivity and thus influences the association between MC and LBP. Importantly, magnetic field strength and pulse sequence parameters also impact detection of MC. Advances in pulse sequences may improve reliability and prove valuable for quantifying lesion severity.
conclusionsComparison of MC data between studies can be problematic. Various methodological factors impact detection and classification of MC, and the lack of reporting guidelines hinders interpretation and comparison of findings. Thus, it is critical to adopt imaging and reporting standards that codify acceptable methodological criteria. These slides can be retrieved under Electronic Supplementary Material.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.