Evidence map›Paper›PMID 31446476›Full record

ArticleCurrent microbiology2019

Improvement of Redox State and Functions of Immune Cells as Well as of Behavioral Response in Aged Mice After Two-Week Supplementation of Fermented Milk with Probiotics.

Caroline Hunsche, Julia Cruces, Mónica De la Fuente

Abstract read
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In one paragraph

Article in Current microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Effects of Commercial Probiotics on Colonic Sensitivity after Acute Mucosal Irritation.International journal of environmental research and public health · 2022
    Article
  6. Article
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Caroline HunscheDepartment of Genetics, Physiology and Microbiology (Unit of Animal Physiology), Faculty of Biology, Complutense University of Madrid, José Antonio Novais Street, 2, 28040, Madrid, Spain.
Julia CrucesDepartment of Genetics, Physiology and Microbiology (Unit of Animal Physiology), Faculty of Biology, Complutense University of Madrid, José Antonio Novais Street, 2, 28040, Madrid, Spain.
Mónica De la FuenteDepartment of Genetics, Physiology and Microbiology (Unit of Animal Physiology), Faculty of Biology, Complutense University of Madrid, José Antonio Novais Street, 2, 28040, Madrid, Spain. mondelaf@bio.ucm.es.
Research Institute Hospital 12 de Octubre · ESUniversidad Complutense de Madrid · ES

Funding

Instituto de Salud Carlos III PI15/01787Research Group of Madrid Complutense University 910379ENEROINN
6 · The paper itself

Abstract

The homeostatic systems, such as the nervous and immune systems, show deterioration in aging as a consequence of the age-related oxidative-inflammatory stress establishment. The supplementation with fermented milk containing probiotic bacteria could be a good nutritional strategy to improve homeostatic system functions in aged individuals through the modulation of their redox state. The aim of the present study was to evaluate the effect of 2-week supplementation with a commercial fermented milk containing yogurt species (Lactobacillus delbrueckii subsp. bulgaricus and Streptococcus thermophilus), and the probiotic Lactobacillus casei DN-114001 on behavior, redox state, and immune cell functions of aged mice as well as on their life span. Aged female ICR-CD1 mice were supplemented with fermented milk containing these probiotics for 2 weeks. After this period, a variety of behavioral tests were performed and several parameters of redox state and function of peritoneal leukocytes were analyzed. The results showed that the 2-week supplementation of fermented milk containing probiotics improved behavior (such as muscular vigor, exploratory activity, and anxiety-like behavior) as well as the redox state and functions of peritoneal immune cells in aged mice. In conclusion, the present study shows that the supplementation with fermented milk containing probiotics for a short period of time could be a good nutritional strategy to promote healthy aging.

Indexed as

AgingAnimalsBehavior, AnimalFemaleHumansImmune SystemLacticaseibacillus caseiLactobacillus delbrueckiiMiceMice, Inbred ICROxidation-ReductionProbioticsStreptococcus thermophilusYogurt

Identifiers

PMID31446476
OpenAlexW2969839224

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.