Evidence map›Paper›PMID 31446366›Full record

ReviewCurrent opinion in microbiology2019

Translocation of effector proteins into host cells by Toxoplasma gondii.

Suchita Rastogi, Alicja M Cygan, John C Boothroyd

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
6.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 63 citations in OpenAlex.

  1. Article
  2. Review
  3. Dense granule proteins: key mediators ofFrontiers in medicine · 2026
    Review
  4. Article
  5. Review
  6. The Distribution ofMicroorganisms · 2025
    Article
  7. Article
  8. mBio · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Cryo-ET reveals the in situ architecture of the polar tube invasion apparatus from microsporidian parasites.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  14. Article
  15. Review
  16. Susceptibility ofmBio · 2024
    Article
  17. AFrontiers in cellular and infection microbiology · 2024
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Suchita RastogiDepartment of Microbiology and Immunology, Fairchild D305, Stanford University School of Medicine, Stanford, CA 94305-5124, USA.
Alicja M CyganDepartment of Microbiology and Immunology, Fairchild D305, Stanford University School of Medicine, Stanford, CA 94305-5124, USA.
John C BoothroydDepartment of Microbiology and Immunology, Fairchild D305, Stanford University School of Medicine, Stanford, CA 94305-5124, USA. Electronic address: jboothr@stanford.edu.
Stanford University · US

Funding

Toxoplasma Rhoptry FunctionR01AI021423 · NIAID · STANFORD UNIVERSITY · PI BOOTHROYD, JOHN C · 1985 to 2018
$7.8M
Identifying The Machinery That Translocates Toxoplasma Effectors Into The Host CellR01AI129529 · NIAID · STANFORD UNIVERSITY · PI BOOTHROYD, JOHN C · 2018 to 2021
$2.2M
NIAID NIH HHS R01 AI021423NIAID NIH HHS R01 AI129529
6 · The paper itself

Abstract

The Apicomplexan parasite, Toxoplasma gondii, is an obligate intracellular organism that must co-opt its host cell to survive. To this end, Toxoplasma parasites introduce a suite of effector proteins from two secretory compartments called rhoptries and dense granules into the host cells. Once inside, these effectors extensively modify the host cell to facilitate parasite penetration, replication and persistence. In this review, we summarize the most recent advances in current understanding of effector translocation from Toxoplasma's rhoptry and dense granule organelles into the host cell, with comparisons to Plasmodium spp. for broader context.

Indexed as

Host-Parasite InteractionsTranslocation, GeneticAnimalsHumansPlasmodiumProtozoan ProteinsToxoplasmaProtozoan Proteins

Identifiers

PMID31446366
PMCPMC6911000
OpenAlexW2969267635

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.