Evidence map›Paper›PMID 31446321›Full record

ArticleEnvironment international2019

Weather, ambient air pollution, and risk of migraine headache onset among patients with migraine.

Wenyuan Li, Suzanne M Bertisch, Elizabeth Mostofsky, Catherine Buettner, Murray A Mittleman

Open access · goldAbstract read
In one paragraph

Article in Environment international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 3 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 3 syntheses or guidelines pooled it, 84 citations in OpenAlex.

  1. Pooled it
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  10. [Clinical analysis of common inhalant allergens in 226 children with epistaxis].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2026
    Article
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  12. Climate Change and Air Pollution-Related Health Effects on Pain.International journal of environmental research and public health · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Wenyuan LiDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. Electronic address: wenyuanli@mail.harvard.edu.
Suzanne M BertischSleep Medicine Epidemiology Program, Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.
Elizabeth MostofskyDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Catherine BuettnerHarvard Medical School, Boston, MA 02115, USA; Department of Medicine, Mount Auburn Hospital, Cambridge, MA 02138, USA.
Murray A MittlemanDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address: mmittlem@hsph.harvard.edu.
Beth Israel Deaconess Medical Center · USBrigham and Women's Hospital · USMount Auburn Hospital · US

Funding

Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2M
Short Sleep Duration and Sleep Disturbance as a Trigger of MigraineR21NS091627 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI BERTISCH, SUZANNE · 2015 to 2016
$498k
NCATS NIH HHS UL1 TR001102NINDS NIH HHS R21 NS091627
6 · The paper itself

Abstract

objectiveMigraine is a common recurrent headache disorder affecting 14% American adults. Although weather and air pollution are often reported by patients with migraine as precipitating factors, previous studies have had mixed results.

methodsWe prospectively collected migraine headache onset data using electronic questionnaires from 98 adults with episodic migraine in the Greater Boston area (2016-2017). Each participant was followed for an average of 45 days for a total of 4406 days of observation. Temperature, relative humidity, and barometric pressure data were obtained from local weather station. Daily average fine particulate matter, daily maximum 1-hour sulfur dioxide, daily maximum 1-hour nitrogen dioxide, daily maximum 8-hour ozone, and daily maximum 8-hour carbon monoxide from local air pollution monitors. We conducted a repeated measures analysis using fixed effects logistic regression models. In the models we adjusted for day of week, a natural cubic spline term of day of the year with 4 degrees of freedom, and a participant identifier. We additionally adjusted for linear terms of temperature and relative humidity in the air pollution analyses. We also applied logistic regression models with generalized estimating equation (GEE) and autoregressive correlation structure in the sensitivity analysis.

resultsThe mean age was 35 years and 88% were women. Mean temperature was 56.9 °F, relative humidity 67.3%, and fine particulate matter 7.3 μg/m

conclusionsWe found that higher relative humidity was associated with higher odds of migraine headache onset in warm season, and traffic-related gaseous pollutants may be associated with higher odds of migraine headache onset in cold season.

Indexed as

WeatherAdultAir PollutantsAir PollutionCarbon MonoxideEnvironmental MonitoringFemaleHeadacheHumansMaleMassachusettsMiddle AgedMigraine DisordersNitrogen DioxideOzoneParticulate MatterAir PollutantsCarbon MonoxideNitrogen DioxideOzoneParticulate MatterSulfur DioxideVehicle EmissionsAir pollutionCohort studyHeadacheMigraine disordersPrecipitating factorsWeather

Identifiers

PMID31446321
PMCPMC7523027
OpenAlexW2969870985

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.