ArticleAtherosclerosis2019
Pregnancy-related events associated with subclinical cardiovascular disease burden in late midlife: SWAN.
Article in Atherosclerosis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- The Association Between Hypertensive Disorders in Pregnancy and the Risk of Developing Chronic Hypertension.Frontiers in cardiovascular medicine · 2022Pooled it
- Women with a history of gestational diabetes mellitus present an accumulation of cardiovascular risk factors at age 46-A birth cohort study.Acta obstetricia et gynecologica Scandinavica · 2024Article
- Pregnancy as an Early Cardiovascular Moment: Peripartum Cardiovascular Health.Circulation research · 2023Review
- Number of prior live births is associated with higher arterial stiffness but not its change in older women: the atherosclerosis risk in communities study.Frontiers in cardiovascular medicine · 2023Article
- High Prevalence of Asymptomatic Intracranial Atherosclerosis in Elder Women With Tubal Ligation: Result From a Community-Based Study in Shandong, China.Frontiers in cardiovascular medicine · 2022Article
- Pregnancy loss is related to body mass index and prediabetes in early adulthood: Findings from Add Health.PloS one · 2022Article
- Addressing Inequities in Cardiovascular Disease and Maternal Health in Black Women.Circulation. Cardiovascular quality and outcomes · 2021Article
- Impact of nulliparity, hypertensive disorders of pregnancy, and gestational diabetes on vasomotor symptoms in midlife women.Menopause (New York, N.Y.) · 2020Article
- Hypertensive disorders of pregnancy and menopausal symptoms: a cross-sectional study from the data registry on experiences of aging, menopause, and sexuality.Menopause (New York, N.Y.) · 2020Article
- Associations of Endogenous Sex Hormones with Carotid Plaque Burden and Characteristics in Midlife Women.The Journal of clinical endocrinology and metabolism · 2020Article
- Hypertensive Disorders of Pregnancy and Future Maternal Health: How Can the Evidence Guide Postpartum Management?Current hypertension reports · 2019Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
aimsReproductive factors are associated with later life CVD in women (e.g., age at first birth, preeclampsia, gestational diabetes), but studies have focused largely on premenopausal women. We examined the relationship of reproductive factors with subclinical CVD burden in late midlife women.
methodsWe included 964 parous women from the Study of Women's Health Across the Nation (SWAN), who completed a reproductive history questionnaire at the 13th SWAN visit (2011-2012), and a carotid ultrasound and brachial-ankle pulse wave velocity (baPWV) assessment. The primary outcomes were carotid intima-media thickness, plaque, and baPWV; our secondary outcome was a composite subclinical CVD index created using these measures. Linear and logistic regression was performed to examine associations with individual subclinical CVD measures, and multinomial logistic regression was used in analyses of the composite index. Models adjusted for socio-demographics and cardiovascular risk factors.
resultsMean age at subclinical CVD assessment was 60.2 years (SD ± 2.7). History of gestational hypertension/preeclampsia was associated with greater carotid IMT (β: 0.038, p = 0.004). Earlier age at first birth was associated with subclinical CVD, but not when accounting for CVD risk factors. History of gestational diabetes was associated with greater baPWV, but not related to our composite index.
conclusionsPregnancy history is an important marker of subclinical CVD in late midlife and may impact the vasculature through distinct pathways. Future studies are necessary to evaluate racial/ethnic differences in the observed associations and to assess the benefit of a composite subclinical CVD index for earlier CVD risk modification in midlife women.
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