ArticleInsect biochemistry and molecular biology2019
DEET and other repellents are inhibitors of mosquito odorant receptors for oviposition attractants.
Article in Insect biochemistry and molecular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 46 citations in OpenAlex.
- Trial
- A natural barrier: tick-repellent potential of a spruce-derived volatile blend against Hyalomma excavatum and Ixodes ricinus.Pest management science · 2026Article
- Odor repellency and neuronal responses of commercial products towards Anopheles mosquitoes.Malaria journal · 2025Article
- Differential Effects of Two Herbivore-Induced Plant Volatiles on the Oviposition ofPlants (Basel, Switzerland) · 2025Article
- The chemosensory world of mosquitoes: olfactory receptors and their role in blocking mosquito-borne disease transmission.Parasites & vectors · 2025Review
- A deep learning and digital archaeology approach for mosquito repellent discovery.Chemical senses · 2025Article
- Lemongrass essential oil and DEET inhibit attractant detection in infected and non-infectedCurrent research in insect science · 2024Article
- Sustainable Pest Management Using Novel Nanoemulsions of Honeysuckle and Patchouli Essential Oils against the West Nile Virus Vector,Plants (Basel, Switzerland) · 2023Article
- The ovipositor cue indole inhibits animal host attraction in Aedes aegypti (Diptera: Culicidae) mosquitoes.Parasites & vectors · 2022Article
- Odorant inhibition in mosquito olfaction mediated by inverse agonists.Biochemical and biophysical research communications · 2022Article
- Genome-wide identification and expression profiling of odorant receptor genes in the malaria vector Anopheles sinensis.Parasites & vectors · 2022Article
- Exposure to N,N-diethyl-Frontiers in public health · 2022Article
- The mosquito taste system and disease control.Proceedings of the National Academy of Sciences of the United States of America · 2020Review
- Chemosensory and Behavioural Responses ofInsects · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In addition to its primary function as an insect repellent, DEET has many "off-label" properties, including a deterrent effect on the attraction of gravid female mosquitoes. DEET negatively affects oviposition sites. While deorphanizing odorant receptors (ORs) using the Xenopus oocyte recording system, we have previously observed that DEET generated outward (inhibitory) currents on ORs sensitive to oviposition attractants. Here, we systematically investigated these inhibitory currents. We recorded dose-dependent outward currents elicited by DEET and other repellents on ORs from Culex quinquefasciatus, Aedes aegypti, and Anopheles gambiae. Similar responses were observed with other plant-derived and plant-inspired compounds, including methyl jasmonate and methyl dihydrojasmolate. Inward (regular) currents elicited by skatole upon activation of CquiOR21 were modulated when this oviposition attractant was coapplied with a repellent. Compounds that generate outward currents in ORs sensitive to oviposition attractants elicited inward currents in a DEET-sensitive receptor, CquiOR136. The best ligand for this receptor, methyl dihydrojasmolate, showed repellency activity but was not as strong as DEET in our test protocol.
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