ArticleJournal of cystic fibrosis : official journal of the European Cystic Fibrosis Society2020
The presence of Aspergillus fumigatus is associated with worse respiratory quality of life in cystic fibrosis.
Article in Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- The airway mycobiome in chronic respiratory diseases: current advances and future frontiers.Journal of translational medicine · 2025Review
- Progression of Structural Lung Disease in DifferentJournal of fungi (Basel, Switzerland) · 2025Article
- How to Assess Fungal Contamination of Indoor Air in Dwellings of Patients with Cystic Fibrosis?Mycopathologia · 2025Article
- Confronting the Fungus among Us in the Airways of People with Cystic Fibrosis.Annals of the American Thoracic Society · 2025Article
- Distribution and Epidemiological Characteristics of Clinical Isolates ofInfection and drug resistance · 2025Article
- Pathogenicity and virulence ofVirulence · 2023Review
- Infection, Allergy, and Inflammation: The Role ofMicroorganisms · 2023Review
- Distinct community structures of the fungal microbiome and respiratory health in adults with cystic fibrosis.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2023Article
- The Clinical Association betweenAnnals of the American Thoracic Society · 2023Article
- Heterologous Expression and Characterization of a Novel Exo-Polygalacturonase fromJournal of microbiology and biotechnology · 2023Article
- Persistent Aspergillus fumigatus infection in cystic fibrosis: impact on lung function and role of treatment of asymptomatic colonization-a registry-based case-control study.BMC pulmonary medicine · 2022Article
- Clinician variability in the diagnosis and treatment of aspergillus fumigatus-related conditions in cystic fibrosis: An international survey.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2022Article
- Review
- The Effects ofJournal of fungi (Basel, Switzerland) · 2021Article
- Cystic Fibrosis Clinical Isolates ofPathogens (Basel, Switzerland) · 2021Article
- Recognition of Diagnostic Gaps for Laboratory Diagnosis of Fungal Diseases: Expert Opinion from the Fungal Diagnostics Laboratories Consortium (FDLC).Journal of clinical microbiology · 2021Article
- Fungal Infection and Inflammation in Cystic Fibrosis.Pathogens (Basel, Switzerland) · 2021Review
- Increased Incidence and Associated Risk Factors of Aspergillosis in Patients with Bronchiectasis.Journal of personalized medicine · 2021Article
- Allergic Diseases Caused byAntibiotics (Basel, Switzerland) · 2021Review
- A retrospective 'real-world' cohort study of azole therapeutic drug monitoring and evolution of antifungal resistance in cystic fibrosis.JAC-antimicrobial resistance · 2021Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundThe clinical effects of Aspergillus fumigatus in the cystic fibrosis (CF) airway, with the exception of allergic bronchopulmonary aspergillosis, is unclear.
methodsCF adolescents and adults (age 14 years and older) underwent bacterial and semi-selective fungal culture testing to determine the prevalence of fungi in the CF respiratory tract and the independent association between the presence of Aspergillus fumigatus and clinical characteristics.
resultsAspergillus fumigatus (10.3%) and Candida species (57.8%) were the most common filamentous fungi and yeast seen respectively in the sputa of 206 individuals with CF. Inhaled corticosteroid (ICS) use was more common in Aspergillus fumigatus-positive than Aspergillus fumigatusnegative (100% versus 75.8%, p = .01). Aspergillus fumigatus was significantly associated with lower respiratory domain score (β -8.74, 95% CI -16.6, -0.88, p = .03), representing worse respiratory-related quality of life, accounting for demographics, disease characteristics, and the presence of a pulmonary exacerbation.
conclusionThe presence of Aspergillus fumigatus in CF sputum was associated with worse respiratory quality of life in CF in a crosssectional, single center study. Longitudinal analysis examining the clinical implications of Aspergillus fumigatus on respiratory health over time is needed.
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