ReviewThe Annals of thoracic surgery2019
The Choice of Treatment in Ischemic Mitral Regurgitation With Reduced Left Ventricular Function.
Review in The Annals of thoracic surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Ischemic functional mitral regurgitation: from pathophysiological concepts to current treatment options. A systemic review for optimal strategy.General thoracic and cardiovascular surgery · 2021Pooled it
- Exploring the Operative Strategy for Secondary Mitral Regurgitation: A Systematic Review.BioMed research international · 2021Pooled it
- Emerging evidence on transcatheter edge-to-edge repair for secondary mitral regurgitation.The Journal of international medical research · 2025Review
- Comparison of surgical outcomes in patients with heart failure with reduced ejection fraction combined with moderate ischemic mitral regurgitation: a single-center retrospective study.Journal of thoracic disease · 2025Article
- Mitral repair with annuloplasty for moderate ischemic mitral regurgitation in people undergoing coronary artery bypass surgery.The Cochrane database of systematic reviews · 2025Article
- Non-coding RNAs in BRAF-mutant melanoma: targets, indicators, and therapeutic potential.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Clinical and echocardiographic outcomes of combined CABG and MV repair.Bioinformation · 2025Article
- Comparing surgical techniques and results of secondary ischemic mitral regurgitation: a state-of-the-art literature review.Annals of translational medicine · 2024Review
- Non-Coding RNA-Targeted Therapy: A State-of-the-Art Review.International journal of molecular sciences · 2024Review
- Moderate Ischemic Mitral Regurgitation with Ejection Fraction <40% Undergoing Concomitant Mitral Valve Repair during Revascularization: A Single-Center Observational Study.Reviews in cardiovascular medicine · 2023Article
- Predictors of Outcomes After Coronary Artery Bypass Grafting: The Effect of Concomitant Mitral Repair.Cureus · 2023Article
- Review
- Impact of Mitral Regurgitation Recurrence on Mitral Valve Repair for Secondary Ischemic Mitral Regurgitation.Journal of cardiovascular development and disease · 2023Article
- Left ventricular remodeling, mechanics, and the COAPT trial.Frontiers in cardiovascular medicine · 2023Article
- Prognosis for Mitral Valve Repair Surgery in Functional Mitral Regurgitation.Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia · 2022Observational
- Impact of ischemia on left atrial remodeling and dysfunction in swine models of mitral regurgitation.American journal of physiology. Heart and circulatory physiology · 2022Article
- Insight from International Guidelines: do We Have Satisfactory Recommendations for Secondary Mitral Regurgitation?Reviews in cardiovascular medicine · 2022Review
- The role of surgery for secondary mitral regurgitation and heart failure in the era of transcatheter mitral valve therapies.Reviews in cardiovascular medicine · 2022Review
- The Use of Subvalvular Repair for Functional Mitral Regurgitation.Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia · 2021Article
- The Use of Radial Artery for CABG: An Update.BioMed research international · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 6 institutions in 3 countries.
Funding
Abstract
backgroundIschemic mitral regurgitation is a condition characterized by mitral insufficiency secondary to an ischemic left ventricle. Primarily, the pathology is the result of perturbation of normal regional left ventricular geometry combined with adverse remodeling. We present a comprehensive review of contemporary surgical, medical, and percutaneous treatment options for ischemic mitral regurgitation, rigorously examined by current guidelines and literature.
methodsWe conducted a literature search of the PubMed database, Embase, and the Cochrane Library (through November 2018) for studies reporting perioperative or late mortality and echocardiographic outcomes after surgical and nonsurgical intervention for ischemic mitral regurgitation.
resultsTreatment of this condition is challenging and often requires a multimodality approach. These patients usually have multiple comorbidities that may preclude surgery as a viable option. A multidisciplinary team discussion is crucial in optimizing outcomes. There are several options for treatment and management of ischemic mitral regurgitation with differing benefits and risks. Guideline-directed medical therapy for heart failure is the treatment choice for moderate and severe ischemic mitral regurgitation, with consideration of coronary revascularization, mitral valve surgery, cardiac resynchronization therapy, or a combination of these, in appropriate candidates. The use of transcatheter mitral valve therapy is considered appropriate in high-risk patients with severe ischemic mitral regurgitation, heart failure, and reduced left ventricular ejection fraction, especially in those with hemodynamic instability.
conclusionsThe role of mitral valve surgery and transcatheter mitral valve therapy continues to evolve.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.