ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2019
Disrupted Habituation in the Early Stage of Psychosis.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 32 citations in OpenAlex.
- Lactate restores PGC1α and BDNF expression rescuing cognitive impairments in a mouse model for schizophrenia.Behavioural brain research · 2026Article
- Progressive Changes Between Thalamic Nuclei and Cortical Networks Across Stimulus-Response Learning.Human brain mapping · 2025Article
- Acute optogenetic induction of the prodromal endophenotype of CA1 hyperactivity causes schizophrenia-related deficits in cognition and salience attribution.Schizophrenia (Heidelberg, Germany) · 2024Article
- The antipsychotic agent sulpiride microinjected into the ventral pallidum restores positive symptom-like habituation disturbance in MAM-E17 schizophrenia model rats.Scientific reports · 2024Article
- Article
- Evidence for functional improvement in reward anticipation in recent onset schizophrenia after one year of coordinated specialty care.Psychological medicine · 2023Article
- Hippocampal Network Dysfunction in Early Psychosis: A 2-Year Longitudinal Study.Biological psychiatry global open science · 2023Article
- Diminished Repetition Suppression Reveals Selective and Systems-Level Face Processing Differences in ASD.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Virtual accident curb risk habituation in workers by restoring sensory responses to real-world warning.iScience · 2023Article
- Cognitive Dysfunction as a Risk Factor for Psychosis.Current topics in behavioral neurosciences · 2023Article
- Distinct contributions of GluA1-containing AMPA receptors of different hippocampal subfields to salience processing, memory and impulse control.Translational psychiatry · 2022Article
- Increased amplitude of hippocampal low frequency fluctuations in early psychosis: A two-year follow-up study.Schizophrenia research · 2022Article
- Automated, open-source segmentation of the Hippocampus and amygdala with the open Vanderbilt archive of the temporal lobe.Magnetic resonance imaging · 2021Article
- Anterior vs Posterior Hippocampal Subfields in an Extended Psychosis Phenotype of Multidimensional Schizotypy in a Nonclinical Sample.Schizophrenia bulletin · 2021Article
- Relational Memory in the Early Stage of Psychosis: A 2-Year Follow-up Study.Schizophrenia bulletin · 2021Article
- Stable habituation deficits in the early stage of psychosis: a 2-year follow-up study.Translational psychiatry · 2021Article
- Relational memory in the early stage of psychotic bipolar disorder.Psychiatry research · 2020Article
- Habituation during encoding: A new approach to the evaluation of memory deficits in schizophrenia.Schizophrenia research · 2020Article
- Evidence for inhibited temperament as a transdiagnostic factor across mood and psychotic disorders.Journal of affective disorders · 2020Article
- Visual exploration differences during relational memory encoding in early psychosis.Psychiatry research · 2020Article
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6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundLearning and memory are impaired in schizophrenia. Some theories have proposed that one form of memory, habituation, is particularly impaired. Preliminary evidence suggests that memory impairment is associated with failed hippocampal habituation in patients with chronic schizophrenia. We studied how abnormal habituation of the hippocampus is related to relational memory deficits in the early stage of psychosis.
methodsWe measured hippocampal activity in 62 patients with early psychosis and 70 healthy individuals using functional magnetic resonance imaging. Habituation was defined as the slope of functional magnetic resonance imaging signal change to repeated presentations of faces and objects. Relational memory ability was measured as the slope of preferential viewing during a face-scene pair eye movement task outside the scanner.
resultsPatients with early psychosis showed impaired relational memory (p < .001) and less hippocampal habituation to objects (p = .01) than healthy control subjects. In the healthy control group, better relational memory was associated with faster anterior hippocampal habituation (faces, r = -.28, p = .03). In contrast, patients with early psychosis showed no brain-behavior relationship (r = .12, p = .40).
conclusionsWe found evidence for disrupted hippocampal habituation in the early stage of psychosis along with an altered association between hippocampal habituation and relational memory ability. These results suggest that neural habituation may provide a novel target for early cognitive interventions in psychosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.