Evidence map›Paper›PMID 31445429›Full record

ArticlePsychoneuroendocrinology2019

Disruption of an enhancer associated with addictive behaviour within the cannabinoid receptor-1 gene suggests a possible role in alcohol intake, cannabinoid response and anxiety-related behaviour.

Elizabeth A Hay, Andrew McEwan, Dana Wilson, Perry Barrett, Giuseppe D'Agostino, Roger G Pertwee, Alasdair MacKenzie

Open access · hybridAbstract read
In one paragraph

Article in Psychoneuroendocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Confirmation of a CausalFrontiers in psychiatry · 2021
    Article
  8. Review
  9. Article
  10. The Epigenetics of the Endocannabinoid System.International journal of molecular sciences · 2020
    Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Elizabeth A HaySchool of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, Foresterhill, University of Aberdeen, Aberdeen AB25 2ZD, UK.
Andrew McEwanSchool of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, Foresterhill, University of Aberdeen, Aberdeen AB25 2ZD, UK.
Dana WilsonRowett Institute of Nutrition and Health, Foresterhill, University of Aberdeen, Aberdeen AB25 2ZD, UK.
Perry BarrettRowett Institute of Nutrition and Health, Foresterhill, University of Aberdeen, Aberdeen AB25 2ZD, UK.
Giuseppe D'AgostinoRowett Institute of Nutrition and Health, Foresterhill, University of Aberdeen, Aberdeen AB25 2ZD, UK.
Roger G PertweeSchool of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, Foresterhill, University of Aberdeen, Aberdeen AB25 2ZD, UK.
Alasdair MacKenzieSchool of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, Foresterhill, University of Aberdeen, Aberdeen AB25 2ZD, UK. Electronic address: mbi167@abdn.ac.uk.
University of Aberdeen · GB

Funding

Biotechnology and Biological Sciences Research Council BB/N017544/1Medical Research Council MR/P009824/1
6 · The paper itself

Abstract

The cannabinoid-1 receptor (CB

Indexed as

Alcohol DrinkingAnimalsAnxietyAnxiety DisordersBehavior, AddictiveBrainCannabinoidsFemaleGenetic Predisposition to DiseaseGenotypeHippocampusHypothalamusIntronsLinkage DisequilibriumMaleMiceCannabinoidsCNR1 protein, mouseReceptor, Cannabinoid, CB1Anxiety-related behaviorCannabinoid-1 receptorCB(1) agonistsCRISPR genome editingEnhancerEthanol intakeGene regulationPharmacogeneticsPolymorphismsTissue specificWin55,212-2

Identifiers

PMID31445429
PMCPMC6857436
OpenAlexW2969064566

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.