ArticleJournal of psychiatric research2019
A polygenic score for body mass index is associated with depressive symptoms via early life stress: Evidence for gene-environment correlation.
Article in Journal of psychiatric research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Body mass index interacts with a genetic-risk score for depression increasing the risk of the disease in high-susceptibility individuals.Translational psychiatry · 2022Pooled it
- Associations among discrimination, genetic susceptibility to inflammation, and C-reactive protein.Brain, behavior, & immunity - health · 2026Article
- Combinatorial effects of gene dosage, polygenic background and environment on complex traits.medRxiv : the preprint server for health sciences · 2026Article
- Parallel Pathways, Divergent Outcomes: Adipose Tissue-Neural Crosstalk in Depression and Obesity.Journal of clinical medicine · 2025Review
- Genotypic and socioeconomic risks for depressive symptoms in two U.S. cohorts spanning early to older adulthood.Journal of psychopathology and clinical science · 2025Article
- From Childhood Obesity to Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and Hyperlipidemia Through Oxidative Stress During Childhood.Metabolites · 2025Review
- Differences in height, weight, and BMI in patients with mood disorders, schizophrenia, and other mental disorders vs. normal controls.Frontiers in psychiatry · 2025Article
- Are season of birth, climate, and parental age predictors of adult temperament, character, anhedonia, suicidality, and self-harm?Frontiers in psychiatry · 2025Article
- Polygenic risk for obesity and body dissatisfaction: beyond BMI.Pediatric research · 2024Article
- Mutational landscape of risk variants in comorbid depression and obesity: a next-generation sequencing approach.Molecular psychiatry · 2024Article
- Evaluating the association between lifestyle factors and heel bone mineral density in different inflammatory states.Heliyon · 2024Article
- Discrimination Exposure and Polygenic Risk for Obesity in Adulthood: Testing Gene-Environment Correlations and Interactions.Lifestyle genomics · 2023Observational
- Favourable Lifestyle Protects Cognitive Function in Older Adults With High Genetic Risk of Obesity: A Prospective Cohort Study.Frontiers in molecular neuroscience · 2022Article
- Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature.Brain sciences · 2021Review
- The Meaning of "Cause" in Genetics.Cold Spring Harbor perspectives in medicine · 2021Article
- Inflammation and Insulin Resistance as Risk Factors and Potential Therapeutic Targets for Alzheimer's Disease.Frontiers in neuroscience · 2021Review
- Vitamin D polygenic score is associated with neuroticism and the general psychopathology factor.Progress in neuro-psychopharmacology & biological psychiatry · 2020Article
- Association between herpes simplex virus 1 exposure and the risk of depression in UK Biobank.Clinical and translational medicine · 2020Article
- The E Is in the G: Gene-Environment-Trait Correlations and Findings From Genome-Wide Association Studies.Perspectives on psychological science : a journal of the Association for Psychological Science · 2020Article
- Polygenic and environmental determinants of tics in the Avon Longitudinal Study of Parents and Children.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric GeneticsArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Increasing childhood obesity rates are associated with not only adverse physical, but also mental health outcomes, including depression. These negative outcomes may be caused and/or exacerbated by the bullying and shaming overweight individuals experience. As body mass index (BMI) can be highly heritable, we hypothesized that a genetic risk for higher BMI, will predict higher early life stress (ELS), which in turn will predict higher depressive symptoms in adulthood. Such a process will reflect an evocative gene-environment correlation (rGE) wherein an individual's genetically influenced phenotype evokes a reaction from the environment that subsequently shapes the individual's health. We modeled genetic risk using a polygenic score of BMI derived from a recent large GWAS meta-analysis. Self-reports were used for the assessment of ELS and depressive symptoms in adulthood. The discovery sample consisted of 524 non-Hispanic Caucasian university students from the Duke Neurogenetics Study (DNS; 278 women, mean age 19.78 ± 1.23 years) and the independent replication sample consisted of 5930 white British individuals from the UK biobank (UKB; 3128 women, mean age 62.66 ± 7.38 years). A significant mediation effect was found in the DNS (indirect effect = 0.207, bootstrapped SE = .10, bootstrapped 95% CI: 0.014 to 0.421), and then replicated in the UKB (indirect effect = 0.04, bootstrapped SE = .01, bootstrapped 95% CI: 0.018 to 0.066). Higher BMI polygenic scores predicted higher ELS, which in turn predicted higher depressive symptoms. Our findings suggest that evocative rGE may contribute to weight-related mental health problems and stress the need for interventions that aim to reduce weight bias, specifically during childhood.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.