Evidence map›Paper›PMID 31445232›Full record

ArticleEuropean journal of medicinal chemistry2019

Design of fluorinated cyclopropane derivatives of 2-phenylcyclopropylmethylamine leading to identification of a selective serotonin 2C (5-HT

Guiping Zhang, John D McCorvy, Sida Shen, Jianjun Cheng, Bryan L Roth, Alan P Kozikowski

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medicinal chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Diazepine Agonists of the 5-HTJournal of medicinal chemistry · 2025
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Guiping ZhangDrug Discovery Program, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60612, United States. Electronic address: guipingz@starwisetrx.com.
John D McCorvyNational Institute of Mental Health Psychoactive Drug Screening Program, and Department of Pharmacology and Division of Chemical Biology and Medicinal Chemistry, University of North Carolina Chapel Hill Medical School, Chapel Hill, NC, 27599, United States.
Sida ShenDepartments of Chemistry, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Discovery, and Center for Developmental Therapeutics, Northwestern University, Evanston, IL, 60208, United States.
Jianjun ChengiHuman Institute, ShanghaiTech University, Shanghai, 201210, China.
Bryan L RothNational Institute of Mental Health Psychoactive Drug Screening Program, and Department of Pharmacology and Division of Chemical Biology and Medicinal Chemistry, University of North Carolina Chapel Hill Medical School, Chapel Hill, NC, 27599, United States.
Alan P KozikowskiDrug Discovery Program, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60612, United States.
National Institute of Mental Health · USUniversity of Illinois Chicago · USNorthwestern University · USShanghaiTech University · CN

Funding

Optimizing Lead 5-HT2c Ligands for Use in the Treatment of SchizophreniaR01MH099993 · NIMH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI CALDARONE, BARBARA J., ROTH, BRYAN L. · 2013 to 2016
$2.8M
NIMH NIH HHS R01 MH099993
6 · The paper itself

Abstract

A new series of fluorinated 5-HT

Indexed as

Drug DesignCyclopropanesDose-Response Relationship, DrugHalogenationHumansMethylaminesMolecular Docking SimulationMolecular StructureReceptor, Serotonin, 5-HT2BReceptor, Serotonin, 5-HT2CStructure-Activity RelationshipcyclopropaneCyclopropanesMethylaminesReceptor, Serotonin, 5-HT2BReceptor, Serotonin, 5-HT2C5-HT(2B) receptor5-HT(2C) receptorAgonistAsymmetric synthesisFluorinated cyclopropane

Identifiers

PMID31445232
PMCPMC6815260
OpenAlexW2967875729

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.