Evidence map›Paper›PMID 31445221›Full record

ArticleMultiple sclerosis and related disorders2019

Vitamin D and MRI measures in progressive multiple sclerosis.

Justin R Abbatemarco, Robert J Fox, Hong Li, Daniel Ontaneda

Abstract read
In one paragraph

Article in Multiple sclerosis and related disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Therapeutic Advances in Multiple Sclerosis.Frontiers in neurology · 2022
    Review
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Justin R AbbatemarcoMellen Center for Multiple Sclerosis, Cleveland Clinic Foundation, Cleveland, OH, USA.
Robert J FoxMellen Center for Multiple Sclerosis, Cleveland Clinic Foundation, Cleveland, OH, USA.
Hong LiQuantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, OH, USA.
Daniel OntanedaMellen Center for Multiple Sclerosis, Cleveland Clinic Foundation, Cleveland, OH, USA. Electronic address: Ontaned@ccf.org.
Cleveland Clinic · US

Funding

Clinical Coordinating Center Network of Excellence in Neuroscience Clinical TrialU01NS077179 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Merit E CUDKOWICZ, Aleksandar Videnovic · 2011 to 2026
$43.4M
Network of Excellence in Neuroscience Clinical Trials (NEXT)-DCCU01NS077352 · NINDS · UNIVERSITY OF IOWA · PI CHRISTOPHER S. COFFEY · 2011 to 2026
$28.1M
Ibudilast Phase II trial in progressive MSU01NS082329 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI FOX, ROBERT J. · 2013 to 2017
$12.5M
Clinical and Translational Science Collaborative of ClevelandKL2TR000440 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$11.1M
NCATS NIH HHS KL2 TR000440NINDS NIH HHS U01 NS077179NINDS NIH HHS U01 NS077352NINDS NIH HHS U01 NS082329
6 · The paper itself

Abstract

backgroundVitamin D deficiency is a proposed risk factor for multiple sclerosis (MS), but its role in progressive MS is not well understood.

objectiveTo examine the association between vitamin D levels and MRI features in primary progressive (PPMS) and secondary progressive MS (SPMS).

methodsSerum 25-hydroxyvitamin D (25[OH]D) and 25-hydroxyvitamin D

results267 patients (age 55.6 ± 7.4, 47.2% male, and 51.3% PPMS) were evaluated with quantitative MRI and vitamin D levels. 25(OH)D and 25(OH)D

conclusions25(OH)D

Indexed as

AdultAgedBrainCalcifediolFemaleGray MatterHumansMagnetic Resonance ImagingMaleMiddle AgedMultiple SclerosisVitamin DWhite Matter25-hydroxyvitamin DCalcifediolVitamin DBrain volumeLesionsMRIPrimary progressive multiple sclerosisProgressive multiple sclerosisSecondary progressive multiple sclerosisVitamin D

Identifiers

PMID31445221
PMCPMC6830523
OpenAlexW2966896291

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.