Trial reportThe Journal of allergy and clinical immunology2019
Common variable immunodeficiency-associated endotoxemia promotes early commitment to the T follicular lineage.
Open access · greenAbstract readClinical TrialMulticenter Study
In one paragraph
Trial report in The Journal of allergy and clinical immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
What it found
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The trial behind it
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Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- Coexistent alterations of BAFF and B-cell phenotypes in complicated CVID course.The Journal of allergy and clinical immunology · 2026Article
- Beyond B cells: T and Innate Immune Mechanisms of Autoimmunity in Common Variable Immunodeficiency.Clinical reviews in allergy & immunology · 2026Review
- Heterozygous NFKB1 variant causes inflammatory dysregulation shaped by broader genetic context in common variable immunodeficiency.JCI insight · 2026Article
- IgA defects in CVID lead to bacterial translocation, increased serum γ-interferon, and BAFF.Journal of human immunity · 2026Article
- T follicular helper cells in primary immune regulatory disorders.The Journal of allergy and clinical immunology · 2025Review
- Gut microbial dysbiosis, IgA, and Enterococcus in common variable immunodeficiency with immune dysregulation.Microbiome · 2025Article
- Maintenance of X chromosome inactivation after T cell activation requires NF-κB signaling.Science immunology · 2024Article
- The common variable immunodeficiency IgM repertoire narrowly recognizes erythrocyte and platelet glycans.The Journal of allergy and clinical immunology · 2024Article
- Comparison of Post-Vaccination Cellular Immune Response in Patients with Common Variable Immune Deficiency.Vaccines · 2024Article
- Cluster analysis of flowcytometric immunophenotyping with extended T cell subsets in suspected immunodeficiency.Immunity, inflammation and disease · 2023Article
- Dysregulated Lymphocyte Antigen Receptor Signaling in Common Variable Immunodeficiency with Granulomatous Lymphocytic Interstitial Lung Disease.Journal of clinical immunology · 2023Article
- IgA deficiency destabilizes homeostasis toward intestinal microbes and increases systemic immune dysregulation.Science immunology · 2023Article
- Human T follicular helper clones seed the germinal center-resident regulatory pool.Science immunology · 2023Article
- Disturbed lipid profile in common variable immunodeficiency - a pathogenic loop of inflammation and metabolic disturbances.Frontiers in immunology · 2023Review
- Distinct CD8 T Cell Populations with Differential Exhaustion Profiles Associate with Secondary Complications in Common Variable Immunodeficiency.Journal of clinical immunology · 2022Article
- Article
- Convergence of cytokine dysregulation and antibody deficiency in common variable immunodeficiency with inflammatory complications.The Journal of allergy and clinical immunology · 2022Article
- Intestinal immunoregulation: lessons from human mendelian diseases.Mucosal immunology · 2021Review
- Phenotypically defined subpopulations of circulating follicular helper T cells in common variable immunodeficiency.Immunity, inflammation and disease · 2020Article
- Immunological and Clinical Phenotyping in Primary Antibody Deficiencies: a Growing Disease Spectrum.Journal of clinical immunology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 5 institutions in 2 countries.
Carole Le CozDivision of Immunology and Allergy, Children's Hospital of Philadelphia, Philadelphia, Pa.
Bertram BengschDepartment of Medicine II, University Medical Center Freiburg, Freiburg, Germany.
Caroline KhannaDivision of Immunology and Allergy, Children's Hospital of Philadelphia, Philadelphia, Pa.
Melissa TrofaDivision of Immunology and Allergy, Children's Hospital of Philadelphia, Philadelphia, Pa.
Takuya OhtaniInstitute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa.
Brian E NolanDivision of Rheumatology, Children's Hospital of Philadelphia, Philadelphia, Pa.
Sarah E HenricksonDivision of Immunology and Allergy, Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa; Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa.
Michele P LambertDivision of Hematology, Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa.
Taylor Olmsted KimDepartment of Pediatrics, Hematology/Oncology Section, Baylor College of Medicine, Houston, Tex.
Jenny M DespotovicDepartment of Pediatrics, Hematology/Oncology Section, Baylor College of Medicine, Houston, Tex.
Scott FeldmanDepartment of Medicine, Division of Allergy and Immunology,Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa.
Olajumoke O FadugbaDepartment of Medicine, Division of Allergy and Immunology,Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa.
Patricia TakachDepartment of Medicine, Division of Allergy and Immunology,Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa.
Melanie RuffnerDivision of Immunology and Allergy, Children's Hospital of Philadelphia, Philadelphia, Pa.
Soma JyonouchiDivision of Immunology and Allergy, Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa.
Jennifer HeimallDivision of Immunology and Allergy, Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa.
Kathleen E SullivanDivision of Immunology and Allergy, Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa; Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa.
E John WherrySystems Pharmacology and Translational Therapeutics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa; Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa.
Neil RombergDivision of Immunology and Allergy, Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa; Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa. Electronic address: rombergn@email.chop.edu.
Children's Hospital of Philadelphia · USUniversity of Pennsylvania · USBaylor College of Medicine · USTranslational Therapeutics (United States) · USUniversity Medical Center Freiburg · DE
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MSynergies among inhibitory receptors in tolerance, cancer & antiviral immunityP01AI108545 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Dario AA Vignali · 2015 to 2026
$30.8MSequencing and Viral Evolution CoreU19AI117950 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI WHERRY, E. JOHN · 2015 to 2019
$12.0MRadiation and checkpoint blockade for cancer immune therapyP01CA210944 · NCI · UNIVERSITY OF PENNSYLVANIA · PI MAITY, AMIT, MINN, ANDY J · 2017 to 2022
$11.5MPediatric Scholars ProgramK12HD043245 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI ST. GEME, JOSEPH W. · 2003 to 2022
$7.4MPromoter interactome-aided mapping of unexplored CVID genetic landscapesR01AI146026 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI ROMBERG, NEIL DAVID · 2019 to 2023
$2.9MCellular and transcriptional control of exhausted CD8 T cells lineage dynamicsR01AI105343 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI WHERRY, E. JOHN · 2014 to 2017
$1.6MBLOCKING AUTOANTIBODY SECRETION IN CVID PATIENTS WITH ITP BY IL-2 RESTORED TREGSK23AI115001 · NIAID · YALE UNIVERSITY · PI ROMBERG, NEIL DAVID · 2015 to 2019
$909kNCATS NIH HHS UL1 TR001863NCI NIH HHS P01 CA210944NIAID NIH HHS K23 AI115001NIAID NIH HHS P01 AI108545NIAID NIH HHS R01 AI105343NIAID NIH HHS R01 AI146026NIAID NIH HHS U19 AI117950NICHD NIH HHS K12 HD043245
Abstract
backgroundAlthough chiefly a B-lymphocyte disorder, several research groups have identified common variable immunodeficiency (CVID) subjects with numeric and/or functional T
objectiveWe sought to determine how circulating CD4
methodsUsing hypothesis-generating, high-dimensional single-cell analyses, we created comprehensive phenotypic maps of circulating CD4
resultsAlthough CD4
conclusionsEndotoxemia is associated with early commitment to the follicular T-cell lineage in IgA-deficient CVID subjects, particularly those with AICs.
Indexed as
AdolescentAdultB-LymphocytesCell DifferentiationChildChild, PreschoolCommon Variable ImmunodeficiencyEndotoxemiaFemaleHumansIgA DeficiencyMaleMiddle AgedT-Lymphocytes, Regulatoryactivin Aautoimmune cytopeniasCommon variable immunodeficiencyendotoxinfollicular helper T cellrecent thymic emigrantregulatory T celltime-of-flight cytometry
Identifiers
What OpenQuestion holds
Textmetadata
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.