ArticleReproductive toxicology (Elmsford, N.Y.)2019
Male exposure to bisphenol A (BPA) and semen quality in the Home Observation of Periconceptional Exposures (HOPE) cohort.
Article in Reproductive toxicology (Elmsford, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Pyrethroids Toxicity to Male Reproductive System and Offspring as a Function of Oxidative Stress Induction: Rodent Studies.Frontiers in endocrinology · 2021Pooled it
- The impact of chemical pollution and warming on male fertility: a narrative review by the Special Interest Group "Environment and Fertility" of the Italian Society of Fertility and Sterility and Reproductive Medicine (SIFES-MR).Journal of assisted reproduction and genetics · 2025Review
- Endocrine Disrupting Agents: Toxicological Aspects on Male Reproduction.Reproductive sciences (Thousand Oaks, Calif.) · 2025Review
- Review
- Decrease in Sperm Parameters in the 21st Century: Obesity, Lifestyle, or Environmental Factors? An Updated Narrative Review.Journal of personalized medicine · 2024Review
- [Association analysis between mixed exposure to phenols and semen quality].Se pu = Chinese journal of chromatography · 2024Article
- Microplastics and environmental effects: investigating the effects of microplastics on aquatic habitats and their impact on human health.Frontiers in public health · 2024Review
- Gestational Exposure to Bisphenol A Causes DNA Hypomethylation and the Upregulation of Progesterone Receptor Expression in the Uterus in Adult Female Offspring Rats.Development & reproduction · 2023Article
- The Correlation of Urine Bisphenol A with Semen Parameters in Men Referred to Infertility Centers: A Cross-Sectional Study.International journal of fertility & sterility · 2023Article
- The Effects of Bisphenol A on Human Male Infertility: A Review of Current Epidemiological Studies.International journal of molecular sciences · 2023Review
- The EU chemicals strategy for sustainability: an opportunity to develop new approaches for hazard and risk assessment.Archives of toxicology · 2022Article
- Sperm Morphology Assessment in the Era of Intracytoplasmic Sperm Injection: Reliable Results Require Focus on Standardization, Quality Control, and Training.The world journal of men's health · 2022Review
- Differential impacts of particulate air pollution exposure on early and late stages of spermatogenesis.Ecotoxicology and environmental safety · 2021Article
- Heterogeneous electro-Fenton process for degradation of bisphenol A using a new graphene/cobalt ferrite hybrid catalyst.Environmental science and pollution research international · 2021Article
- Microplastics: A Threat for Male Fertility.International journal of environmental research and public health · 2021Review
- Urinary Bisphenol A, F and S Levels and Semen Quality in Young Adult Danish Men.International journal of environmental research and public health · 2021Article
- Endocrine Disrupting Chemicals and Reproductive Health in Boys and Men.Frontiers in endocrinology · 2021Review
- Low doses of Bisphenol S affect post-translational modifications of sperm proteins in male mice.Reproductive biology and endocrinology : RB&E · 2020Article
- Mechanisms of Testicular Disruption from Exposure to Bisphenol A and Phtalates.Journal of clinical medicine · 2020Review
- Bisphenol A and Male Fertility: Myths and Realities.Frontiers in endocrinology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundExposure to bis-phenol A (BPA) has been associated with reduced semen quality. The objective of this study was to examine associations between BPA measured in serial daily first-morning urine samples and semen quality parameters among men trying to conceive.
methodsThis prospective, preconception cohort included 161 men ages 18-40 without known subfertility. Men collected daily, first morning urine during their female partner's fertile window. Semen samples were collected through intercourse after the fertile window.
resultsSamples from 161 men were analyzed. Higher geometric mean (GM) BPA exposures (ng/mL) were found among men with abnormal sperm tail morphology (GM = 3.12, 95% CI = 2.43, 4.01) compared to men with normal morphologic findings (GM = 2.39, 95% CI = 2.17, 2.74). There was no association with sperm count.
conclusionHigher exposure to BPA was associated with abnormal sperm tail morphology in this prospective, pre-conception cohort.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.