Evidence map›Paper›PMID 31445030›Full record

ArticleBrain research2019

Serotonin abnormalities in Dravet syndrome mice before and after the age of seizure onset.

Paul G Hatini, Kathryn G Commons

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Paul G HatiniDepartment of Anesthesiology, Perioperative and Pain Medicine, Children's Hospital, Boston, Department of Anæsthesia, Harvard Medical School, United States.
Kathryn G CommonsDepartment of Anesthesiology, Perioperative and Pain Medicine, Children's Hospital, Boston, Department of Anæsthesia, Harvard Medical School, United States. Electronic address: Kathryn.Commons@childrens.harvard.edu.
Harvard University · US

Funding

VENTRAL MEDULLA, BREATHING, AND CENTRAL CHEMORECEPTIONP01HD036379 · NICHD · HARVARD MEDICAL SCHOOL · PI KINNEY, HANNAH CHASE · 1998 to 2017
$32.2M
Topography of Serotonin DysfunctionR01DA021801 · NIDA · BOSTON CHILDREN'S HOSPITAL · PI COMMONS, KATHRYN G · 2007 to 2018
$3.6M
NICHD NIH HHS P01 HD036379NIDA NIH HHS R01 DA021801
6 · The paper itself

Abstract

Dravet syndrome (DS) is a genetic form of severe epilepsy often associated with mutation of the SCN1A gene encoding the voltage gated sodium channel Nav1.1. Typically refractive to conventional therapy, serotonin neurotransmission may be an innovative target for treatment. To further understand the role of serotonin in this disorder, in this study we examined the state of the endogenous serotonin system in an Scn1a

Indexed as

Age FactorsAnimalsBrainDisease Models, AnimalEpilepsies, MyoclonicEpilepsyFemaleMaleMiceMice, Inbred C57BLMice, KnockoutMutationNAV1.1 Voltage-Gated Sodium ChannelReceptor, Serotonin, 5-HT1ASeizuresSerotoninNAV1.1 Voltage-Gated Sodium ChannelReceptor, Serotonin, 5-HT1AScn1a protein, mouseSerotoninSerotonin 5-HT1 Receptor AgonistsEpilepsyNav1.1RapheScn1ASeizureSerotonin

Identifiers

PMID31445030
PMCPMC6922539
OpenAlexW2969988735

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.