Preparation of dihydroxy polycyclic aromatic hydrocarbons and activities of two dioxygenases in the phenanthrene degradative pathway.

Kaci L Erwin, William H Johnson, Andrew J Meichan, Christian P Whitman

Abstract read

In one paragraph

Article in Archives of biochemistry and biophysics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Kaci L ErwinDepartment of Molecular Biosciences, College of Natural Sciences, 1 University Station, University of Texas, Austin, TX, 78712, USA.

William H JohnsonDivision of Chemical Biology and Medicinal Chemistry, College of Pharmacy, 1 University Station, University of Texas, Austin, TX, 78712, USA.

Andrew J MeichanDivision of Chemical Biology and Medicinal Chemistry, College of Pharmacy, 1 University Station, University of Texas, Austin, TX, 78712, USA.

Christian P WhitmanDivision of Chemical Biology and Medicinal Chemistry, College of Pharmacy, 1 University Station, University of Texas, Austin, TX, 78712, USA. Electronic address: whitman@austin.utexas.edu.

Funding

ENZYMES OF THE META-FISSION PATHWAYR01GM041239 · NIGMS · UNIVERSITY OF TEXAS AUSTIN · PI WHITMAN, CHRISTIAN P. · 1995 to 2017

$3.0M

Bruker AVANCE III HD 500 MHz NMRS10OD021508 · OD · UNIVERSITY OF TEXAS AT AUSTIN · PI SESSLER, JONATHAN L · 2016 to 2016

$529k

NIGMS NIH HHS R01 GM041239NIH HHS S10 OD021508

6 · The paper itself

Abstract

Dihydroxy phenanthrene, fluoranthene, and pyrene derivatives are intermediates in the bacterial catabolism of the corresponding parent polycyclic aromatic hydrocarbon (PAH). Ring-opening of the dihydroxy species followed by a series of enzyme-catalyzed reactions generates metabolites that funnel into the Krebs Cycle with the eventual production of carbon dioxide and water. One complication in delineating these pathways and harnessing them for useful purposes is that the initial enzymatic processing produces multiple dihydroxy PAHs with multiple ring opening possibilities and products. As part of a systematic effort to address this issue, eight dihydroxy species were synthesized and characterized as the dimethoxy or diacetate derivatives. Several dihydroxy compounds were examined with two dioxygenases in the phenanthrene degradative pathway in Mycobacterium vanbaalenii PYR-1. One, 3,4-dihydroxyphenanthrene, was processed by PhdF with a k

Indexed as

BiocatalysisDioxygenasesEnvironmental PollutantsPhenanthrenesDioxygenasesEnvironmental PollutantsPhenanthrenesDioxygenasesEnzyme kineticsPhenanthrenePolycyclic aromatic hydrocarbons

Identifiers

PMID31445023

DOI10.1016/j.abb.2019.108081

PMCPMC6746177

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.