ArticleJournal of veterinary internal medicine2019
Diagnostic potential of simplified methods for measuring glomerular filtration rate to detect chronic kidney disease in dogs.
Article in Journal of veterinary internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 7 citations in OpenAlex.
- Evaluation of glomerular filtration rate estimation through plasma clearance of iohexol in seagulls (Larus michahellis).BMC veterinary research · 2025Article
- Early Detection of Chronic Kidney Disease Using Plasma Neutrophil Gelatinase-Associated Lipocalin and Kidney Injury Molecule-1 in Small-Breed Dogs: A Retrospective Pilot Study.Animals : an open access journal from MDPI · 2024Article
- Drug-Dosing Adjustment in Dogs and Cats with Chronic Kidney Disease.Animals : an open access journal from MDPI · 2022Review
- Advancement of pharmacokinetic models of iohexol in patients aged 70 years or older with impaired kidney function.Scientific reports · 2021Article
- Population Pharmacokinetic Model of Iohexol in Dogs to Estimate Glomerular Filtration Rate and Optimize Sampling Time.Frontiers in pharmacology · 2021Article
- Diagnostic potential of simplified methods for measuring glomerular filtration rate to detect chronic kidney disease in dogs.Journal of veterinary internal medicine · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGlomerular filtration rate (GFR) is the most sensitive indicator of initial renal function decline during chronic kidney disease (CKD), but conventional protocols for measuring GFR are labor-intensive and stressful for the dog.
objectivesTo assess the diagnostic potential for detecting CKD with simplified GFR protocols based on iohexol plasma clearance. ANIMALS: Seventeen CKD-positive and 23 CKD-negative dogs of different breeds and sex.
methodsProspective nonrandomized study. Plasma iohexol was measured 5, 15, 60, 90, and 180 minutes after injection. Glomerular filtration rate was calculated using 5 samples (GFR
resultsAll simplified protocols gave reliable GFR measurements, comparable to reference GFR
conclusionsThe simplified GFR protocols offer an accurate, hands-on tool for CKD diagnosis in dogs. The gray zone might help decision-making in the management of early kidney dysfunction.
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