ArticleHuman brain mapping2019
Targeting age-related differences in brain and cognition with multimodal imaging and connectome topography profiling.
Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed.
- Spatiotemporal Characterization of the Functional MRI Latency Structure with Respect to Neural Signaling and Brain Hierarchy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The uniqueness of human vulnerability to brain aging in great ape evolution.Science advances · 2024Article
- Edge-Community Entropy Is a Novel Neural Correlate of Aging and Moderator of Fluid Cognition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Tau follows principal axes of functional and structural brain organization in Alzheimer's disease.Nature communications · 2024Article
- A Subtype Perspective on Cognitive Trajectories in Healthy Aging.Brain sciences · 2024Article
- Identifying subgroups of eating behavior traits unrelated to obesity using functional connectivity and feature representation learning.Human brain mapping · 2024Article
- Connectome-based modelling of neurodegenerative diseases: towards precision medicine and mechanistic insight.Nature reviews. Neuroscience · 2023Review
- Correspondence of functional connectivity gradients across human isocortex, cerebellum, and hippocampus.Communications biology · 2023Article
- Disorganization of language and working memory systems in frontal versus temporal lobe epilepsy.Brain : a journal of neurology · 2023Article
- BrainStat: A toolbox for brain-wide statistics and multimodal feature associations.NeuroImage · 2023Article
- Individual functional parcellation revealed compensation of dynamic limbic network organization in healthy ageing.Human brain mapping · 2023Article
- Multiscale neural gradients reflect transdiagnostic effects of major psychiatric conditions on cortical morphology.Communications biology · 2022Article
- Inter- and intra-individual variation in brain structural-cognition relationships in aging.NeuroImage · 2022Article
- The many dimensions of human hippocampal organization and (dys)function.Trends in neurosciences · 2021Review
- Structural Connectivity Gradients of the Temporal Lobe Serve as Multiscale Axes of Brain Organization and Cortical Evolution.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- The BigBrainWarp toolbox for integration of BigBrain 3D histology with multimodal neuroimaging.eLife · 2021Article
- Association between hippocampal structure and serum Brain-Derived Neurotrophic Factor (BDNF) in healthy adults: A registered report.NeuroImage · 2021Article
- Inter-individual body mass variations relate to fractionated functional brain hierarchies.Communications biology · 2021Article
- Oxidative stress and impaired oligodendrocyte precursor cell differentiation in neurological disorders.Cellular and molecular life sciences : CMLS · 2021Review
- Functional Connectivity and Compensation of Phonemic Fluency in Aging.Frontiers in aging neuroscience · 2021Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Aging is characterized by accumulation of structural and metabolic changes in the brain. Recent studies suggest transmodal brain networks are especially sensitive to aging, which, we hypothesize, may be due to their apical position in the cortical hierarchy. Studying an open-access healthy cohort (n = 102, age range = 30-89 years) with MRI and Aβ PET data, we estimated age-related cortical thinning, hippocampal atrophy and Aβ deposition. In addition to carrying out surface-based morphological and metabolic mapping experiments, we stratified effects along neocortical and hippocampal resting-state functional connectome gradients derived from independent datasets. The cortical gradient depicts an axis of functional differentiation from sensory-motor regions to transmodal regions, whereas the hippocampal gradient recapitulates its long-axis. While age-related thinning and increased Aβ deposition occurred across the entire cortical topography, increased Aβ deposition was especially pronounced toward higher-order transmodal regions. Age-related atrophy was greater toward the posterior end of the hippocampal long-axis. No significant effect of age on Aβ deposition in the hippocampus was observed. Imaging markers correlated with behavioral measures of fluid intelligence and episodic memory in a topography-specific manner, confirmed using both univariate as well as multivariate analyses. Our results strengthen existing evidence of structural and metabolic change in the aging brain and support the use of connectivity gradients as a compact framework to analyze and conceptualize brain-based biomarkers of aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.