ArticleHuman brain mapping2019
Preserved network functional connectivity underlies cognitive reserve in multiple sclerosis.
Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 61 citations in OpenAlex.
- Multi-compartment Myelin Streamline Decomposition reveals tract-specific and global brain network myelination in Multiple Sclerosis.Neuroimage. Reports · 2026Article
- Prognostic factors in paediatric-onset multiple sclerosis: a narrative review.Journal of neurology · 2026Review
- Mediating effect of cognitive reserve on associations between processing speed and memory in older adults with and without multiple sclerosis.Neuropsychology · 2026Article
- Preserved α2 oscillations underpin reserve-related resilience of semantic verbal fluency in multiple sclerosis.Frontiers in neuroscience · 2026Article
- Cognitive outcomes in multiple sclerosis are shaped by divergent functional connectivity trajectories.Brain communications · 2026Article
- The protective role of cognitive reserve in moderating depressive symptomatology in patients with multiple sclerosis.BMC psychology · 2025Article
- An interdisciplinary approach is necessary in the treatment of cognitive decline in multiple sclerosis: Yes.Multiple sclerosis (Houndmills, Basingstoke, England) · 2025Article
- Human restrictedFrontiers in neuroscience · 2024Article
- Compensatory mechanisms amidst demyelinating disorders: insights into cognitive preservation.Brain communications · 2024Article
- Cognitive function in severe progressive multiple sclerosis.Brain communications · 2024Article
- Cortical and Subcortical Brain Atrophy Assessment Using Simple Measures on NCCT Compared with MRI in Acute Stroke.AJNR. American journal of neuroradiology · 2023Article
- A multimodal marker for cognitive functioning in multiple sclerosis: the role of NfL, GFAP and conventional MRI in predicting cognitive functioning in a prospective clinical cohort.Journal of neurology · 2023Article
- Resting-state functional connectivity is modulated by cognitive reserve in early Parkinson's disease.Frontiers in psychology · 2023Article
- Multiple sclerosis progression: time for a new mechanism-driven framework.The Lancet. Neurology · 2023Review
- Associations between corpus callosum damage, clinical disability, and surface-based homologous inter-hemispheric connectivity in multiple sclerosis.Brain structure & function · 2022Article
- Functional network dynamics and decreased conscientiousness in multiple sclerosis.Journal of neurology · 2022Article
- The network collapse in multiple sclerosis: An overview of novel concepts to address disease dynamics.NeuroImage. Clinical · 2022Review
- Structural disconnection and functional reorganization in Fabry disease: a multimodal MRI study.Brain communications · 2022Article
- Subtyping relapsing-remitting multiple sclerosis using structural MRI.Journal of neurology · 2021Article
- Neuroimaging Correlates of Cognitive Dysfunction in Adults with Multiple Sclerosis.Brain sciences · 2021Review
Corrections and comments
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Authors and funding
15 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cognitive reserve is one's mental resilience or resistance to the effects of structural brain damage. Reserve effects are well established in people with multiple sclerosis (PwMS) and Alzheimer's disease, but the neural basis of this phenomenon is unclear. We aimed to investigate whether preservation of functional connectivity explains cognitive reserve. Seventy-four PwMS and 29 HCs underwent neuropsychological assessment and 3 T MRI. Structural damage measures included gray matter (GM) atrophy and network white matter (WM) tract disruption between pairs of GM regions. Resting-state functional connectivity was also assessed. PwMS exhibited significantly impaired cognitive processing speed (t = 2.14, p = .037) and visual/spatial memory (t = 2.72, p = .008), and had significantly greater variance in functional connectivity relative to HCs within relevant networks (p < .001, p < .001, p = .016). Higher premorbid verbal intelligence, a proxy for cognitive reserve, predicted relative preservation of functional connectivity despite accumulation of GM atrophy (standardized-β = .301, p = .021). Furthermore, preservation of functional connectivity attenuated the impact of structural network WM tract disruption on cognition (β = -.513, p = .001, for cognitive processing speed; β = -.209, p = .066, for visual/spatial memory). The data suggests that preserved functional connectivity explains cognitive reserve in PwMS, helping to maintain cognitive capacity despite structural damage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.