ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2019
Indoor dust acts as an adjuvant to promote sensitization to peanut through the airway.
Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 46 citations in OpenAlex.
- The Role of the Indoor Exposome in Food Allergy Development.Current allergy and asthma reports · 2026Review
- Decoding Early Clues: Immune Mechanisms, Prevention, Diagnosis, and Treatment of IgE-Mediated Peanut and Tree Nut Allergy in Children.Biomedicines · 2025Review
- Deficiency of H3K27 histone demethylase UTX in T cells blunts allergic sensitization and anaphylaxis to peanut.ImmunoHorizons · 2025Article
- Allergens in Atopic Dermatitis.Clinical reviews in allergy & immunology · 2025Review
- Impaired cell viability and mitochondrial respiration by disperse textile dyes.Frontiers in allergy · 2025Article
- Prevention of IgE-Mediated Food Allergy: Emerging Strategies Through Maternal and Neonatal Interventions.The journal of allergy and clinical immunology. In practice · 2024Review
- Different airborne particulates trigger distinct immune pathways leading to peanut allergy in a mouse model.Allergy · 2024Article
- A single priming event prevents oral tolerance to peanut.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2023Article
- Environmental Exposure to Foods as a Risk Factor for Food Allergy.Current allergy and asthma reports · 2023Review
- Reactivity of nasal cavity mucosa in the nasal cow's milk allergen provocation test.Postepy dermatologii i alergologii · 2023Article
- Preclinical evaluation of alternatives to oral immunotherapy for food allergies.Frontiers in allergy · 2023Review
- Peanut lipids influence the response of bronchial epithelial cells to the peanut allergens Ara h 1 and Ara h 2 by decreasing barrier permeability.Frontiers in molecular biosciences · 2023Article
- Peanut butter feeding induces oral tolerance in genetically diverse collaborative cross mice.Frontiers in allergy · 2023Article
- Androgen receptor signaling protects male mice from the development of immune response to peanut.American journal of clinical and experimental immunology · 2023Article
- Enterosorbents in complex therapy of food allergies: a focus on digestive disorders and systemic toxicity in children.Frontiers in immunology · 2023Review
- Clinical Manifestations of Pediatric Food Allergy: a Contemporary Review.Clinical reviews in allergy & immunology · 2022Review
- An Overview of Environmental Risk Factors for Food Allergy.International journal of environmental research and public health · 2022Review
- Understanding sex differences in the allergic immune response to food.AIMS allergy and immunology · 2022Article
- The airway as a route of sensitization to peanut: An update to the dual allergen exposure hypothesis.The Journal of allergy and clinical immunology · 2021Review
- Timing of exposure to environmental adjuvants is critical to mitigate peanut allergy.The Journal of allergy and clinical immunology · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThere is growing evidence that environmental peanut exposure through non-oral routes, including the skin and respiratory tract, can result in peanut sensitization. Environmental adjuvants in indoor dust can promote sensitization to inhaled antigens, but whether they contribute to peanut allergy development is unclear.
objectiveWe investigated whether indoor dust promotes airway sensitization to peanut and peanut allergy development in mice.
methodsFemale and male C57BL/6J mice were exposed via the airways to peanut, indoor dust extract, or both for 2 weeks. Mice were then challenged with peanut and assessed for anaphylaxis. Peanut-specific immunoglobulins, peanut uptake by lung conventional dendritic cells (cDCs), lung innate cytokines, and T cell differentiation in lung-draining lymph nodes were quantified. Innate cytokine production by primary human bronchial epithelial cells exposed to indoor dust was also determined.
resultsInhalational exposure to low levels of peanut in combination with indoor dust, but neither alone, resulted in production of peanut-specific IgE and development of anaphylaxis upon peanut challenge. Indoor dust triggered production of innate cytokines in murine lungs and in primary human bronchial epithelial cells. Additionally, inhaled indoor dust stimulated maturation and migration of peanut-laden lung type 1 cDCs to draining lymph nodes. Inhalational exposure to peanut and indoor dust induced peanut-specific T helper 2 cell differentiation and accumulation of T follicular helper cells in draining lymph nodes, which were associated with increased B cell numbers and peanut-specific immunoglobulin production. CONCLUSIONS & CLINICAL RELEVANCE: Indoor dust promotes airway sensitization to peanut and development of peanut allergy in mice. Our findings suggest that environmental adjuvants in indoor dust may be determinants of peanut allergy development in children.
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