Evidence map›Paper›PMID 31444693›Full record

ArticleClinical oral investigations2020

The modulation of the TREM-1/PGLYRP1/MMP-8 axis in peri-implant diseases.

Mayla K S Teixeira, Ronaldo Lira-Junior, Eduardo José Veras Lourenço, Daniel Moraes Telles, Elisabeth A Boström, Carlos Marcelo Figueredo, Nagihan Bostanci

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Article in Clinical oral investigations, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Levels of Gene Expression of Immunological Biomarkers in Peri-Implant and Periodontal Tissues.International journal of environmental research and public health · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Mayla K S TeixeiraDepartment of Prosthodontics Faculty of Odontology, Rio de Janeiro State University, Rio de Janeiro, Brazil.
Ronaldo Lira-JuniorDepartment of Periodontology Faculty of Odontology, Rio de Janeiro State University, Rio de Janeiro, Brazil.
Eduardo José Veras LourençoDepartment of Prosthodontics Faculty of Odontology, Rio de Janeiro State University, Rio de Janeiro, Brazil.
Daniel Moraes TellesDepartment of Prosthodontics Faculty of Odontology, Rio de Janeiro State University, Rio de Janeiro, Brazil.
Elisabeth A BoströmKarolinska Institutet, Department of Dental Medicine, Division of Oral Diseases, Stockholm, Sweden.
Carlos Marcelo FigueredoDepartment of Periodontology Faculty of Odontology, Rio de Janeiro State University, Rio de Janeiro, Brazil. c.dasilvafigueredo@griffith.edu.au.
Nagihan BostanciKarolinska Institutet, Department of Dental Medicine, Division of Oral Diseases, Stockholm, Sweden.
Karolinska Institutet · SEUniversidade do Estado do Rio de Janeiro · BRGriffith University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe aim of this study is to investigate the expression of sTREM-1 and its ligand PGLYRP1, as well as the expression of MMP-8 and its inhibitor TIMP-1, in peri-implant diseases. As a secondary aim, we analyzed the influence of the concomitant existence of periodontitis in the expression of these biomarkers. MATERIALS AND

methodsThis study included 77 patients (29 males and 48 females; mean age 55.0 ± 11.5), 18 having gingivitis, 16 having periodontitis, 20 having mucositis, and 23 having peri-implantitis. Patients were clinically examined, and unstimulated whole saliva was collected. sTREM-1, PGLYRP1, MMP-8, TIMP-1, and MMP-8/TIMP1 ratio were determined by ELISA.

resultsThe periodontitis group presented higher probing depth (PD) mean, and higher clinical attachment loss, compared with the other groups. The peri-implantitis group presented higher PD mean in implants compared to the mucositis group. Patients with PD ≥ 6 mm showed significantly higher levels of PGLYRP1, MMP-8, and MMP-8/TIMP-1 ratio than patients with PD < 6 mm. When all four markers were assessed, there were no significant differences between mucositis and peri-implantitis groups. Concomitant periodontitis resulted in higher significant levels of MMP-8 in patients with peri-implant disease.

conclusionWe did not observe significant differences in the levels of the sTREM-1/PGLYRP1/MMP-8 axis between patients with periodontal and peri-implant diseases, suggesting that these markers are also involved in the inflammatory process around implants. Besides, the presence of periodontitis may affect the levels of MMP-8 in patients with peri-implant disease. CLINICAL RELEVANCE: The sTREM-1/PGLYRP1/MMP-8 axis could be useful as potent markers in periodontal and peri-implant diseases.

Indexed as

Dental ImplantsAdultAgedCytokinesFemaleHumansMaleMatrix Metalloproteinase 8Middle AgedPeri-ImplantitisPeriodontitisTissue Inhibitor of Metalloproteinase-1Triggering Receptor Expressed on Myeloid Cells-1CytokinesDental ImplantsMatrix Metalloproteinase 8MMP8 protein, humanPGLYRP1 protein, humanTIMP1 protein, humanTissue Inhibitor of Metalloproteinase-1TREM1 protein, humanTriggering Receptor Expressed on Myeloid Cells-1MMP-8MucositisPeri-implantitisPeriodontitisPGLYRP1TREM-1

Identifiers

PMID31444693
OpenAlexW2969847786

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.