Evidence map›Paper›PMID 31444679›Full record

ReviewSleep & breathing = Schlaf & Atmung2020

Excessive daytime sleepiness and fatigue in neurological disorders.

Michelangelo Maestri, Andrea Romigi, Alessandro Schirru, Monica Fabbrini, Sara Gori, Ubaldo Bonuccelli, Enrica Bonanni

Abstract readReview
PubMed Publisher
In one paragraph

Review in Sleep & breathing = Schlaf & Atmung, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 72 citations in OpenAlex.

  1. A gradual and sustainable approach to diagnosing sleep and circadian disturbances in dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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  6. Cognition and psychomotor vigilance in treated sleep apnea patients with and without daytime sleepiness: the MAGNETO study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Michelangelo MaestriDepartment of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Via Roma 67, 56126, Pisa, Italy. m.maestri@ao-pisa.toscana.it.ORCID http://orcid.org/0000-0003-0960-4938
Andrea RomigiSleep Medicine Center, IRCCS Neuromed, Pozzilli, IS, Italy.
Alessandro SchirruDepartment of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Via Roma 67, 56126, Pisa, Italy.
Monica FabbriniDepartment of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Via Roma 67, 56126, Pisa, Italy.
Sara GoriDepartment of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Via Roma 67, 56126, Pisa, Italy.
Ubaldo BonuccelliDepartment of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Via Roma 67, 56126, Pisa, Italy.
Enrica BonanniDepartment of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Via Roma 67, 56126, Pisa, Italy.
University of Pisa · ITIstituto Neurologico Mediterraneo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Excessive daytime sleepiness (EDS) and fatigue are some of the most frequent symptoms in neurological diseases and could impact on quality of life by increasing the risk of accidents and generally affecting daily life activities. In this review, we will examine the variety of causes responsible for EDS in neurological diseases, including nocturnal sleep alterations, CNS pathological abnormalities with alterations in arousal and/or REM regulation systems, circadian rhythms disorders, drugs, and comorbid psychiatric or primary sleep disorders. Among neurological diseases, epilepsy, dementia, Parkinson disease, multiple sclerosis, and myotonic dystrophies represented a model for these interactions between EDS and neurological diseases. A complete diagnostic workup in neurological patients with EDS should be undertaken since EDS can worsen many different aspects such as psychiatric symptoms, cognitive deficit, and in some cases, the severity of the neurological disease per se. Moreover, quality of life and risk of accidents are dependent on EDS. An individualized approach to this symptom in neurological patients should be considered with a focus on modifiable causes such as SDB, psychiatric comorbidities, and drugs. When considering EDS and fatigue in neurological diseases, close attention to lifestyle and sleep hygiene is advisable. A critical review of ongoing pharmacological therapy should not be overlooked. Possible diagnosis and treatment of SDB should be always considered.

Indexed as

Disorders of Excessive SomnolenceFatigueHumansNervous System DiseasesDementiaEpilepsyExcessive daytime sleepinessFatigueHeadacheMyotonic dystrophiesParkinson disease

Identifiers

PMID31444679
OpenAlexW2969475132

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.