Evidence map›Paper›PMID 31444591›Full record

ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2019

Increased markers of cardiac vagal activity in leucine-rich repeat kinase 2-associated Parkinson's disease.

Claudia Carricarte Naranjo, Connie Marras, Naomi P Visanji, David J Cornforth, Lazaro Sanchez-Rodriguez, Birgitt Schüle, Samuel M Goldman, Mario Estévez, Phyllis K Stein, Anthony E Lang and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Heartbeat signature for predicting motor and non-motor involvement among nonparkinsonian LRRK2 G2019S mutation carriers.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025
    Article
  2. Review
  3. Article
  4. Review
  5. Short-term deceleration capacity of heart rate: a sensitive marker of cardiac autonomic dysfunction in idiopathic Parkinson's disease.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021
    Article
  6. Review
  7. Genetic and Environmental Factors Influence the Pleomorphy ofInternational journal of molecular sciences · 2021
    Review
  8. Article
  9. Dysautonomia in the synucleinopathies: not just orthostatic hypotension.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 4 countries.

Claudia Carricarte NaranjoFacultad de Biología, Universidad de La Habana, Calle 25 No. 455, Vedado, Plaza de la Revolución, 10400, La Habana, Cuba. carri@fbio.uh.cu.ORCID 0000-0001-8764-3583
Connie MarrasEdmond J Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, 399 Bathurst St, Toronto, ON, M5T 2S8, Canada.
Naomi P VisanjiEdmond J Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, 399 Bathurst St, Toronto, ON, M5T 2S8, Canada.
David J CornforthSchool of Electrical Engineering and Computing, University of Newcastle, University Dr, Callaghan, NSW, 2308, Australia.
Lazaro Sanchez-RodriguezDepartment of Radiology, University of Calgary, 330 Hospital Dr NW, Calgary, AB, T2N 4N1, Canada.
Birgitt SchüleDepartment of Pathology, Stanford School of Medicine, 300 Pasteur Dr, R271, Stanford, CA, 94305, USA.
Samuel M GoldmanDepartment of Neurology, University of California, 3333 California St, San Francisco, CA, 94118, USA.
Mario EstévezDepartamento de Neurofisiología Clínica, Instituto de Neurología y Neurocirugía, Calle 29 No. 139, Vedado, Plaza de la Revolución, 10400, La Habana, Cuba.
Phyllis K SteinSchool of Medicine, Washington University, 660 S Euclid Ave, St. Louis, MO, 63110, USA.
Anthony E LangEdmond J Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, 399 Bathurst St, Toronto, ON, M5T 2S8, Canada.
Herbert F JelinekSchool of Community Health, Charles Sturt University, Elizabeth Mitchell Dr, Albury, NSW, 2640, Australia.
Andrés MachadoFacultad de Biología, Universidad de La Habana, Calle 25 No. 455, Vedado, Plaza de la Revolución, 10400, La Habana, Cuba.
Toronto Western Hospital · CAUniversity of Havana · CUCharles Sturt University · AUInstituto de Neurologia Y Neurocirugia · CUStanford Medicine · USUniversity of Calgary · CAUniversity of California, San Francisco · USUniversity of Newcastle Australia · AUWashington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeCardiac autonomic dysfunction manifests as reduced heart rate variability (HRV) in idiopathic Parkinson's disease (PD), but no significant reduction has been found in PD patients who carry the LRRK2 mutation. Novel HRV features have not been investigated in these individuals. We aimed to assess cardiac autonomic modulation through standard and novel approaches to HRV analysis in individuals who carry the LRRK2 G2019S mutation.

methodsShort-term electrocardiograms were recorded in 14 LRRK2-associated PD patients, 25 LRRK2-non-manifesting carriers, 32 related non-carriers, 20 idiopathic PD patients, and 27 healthy controls. HRV measures were compared using regression modeling, controlling for age, sex, mean heart rate, and disease duration. Discriminant analysis highlighted the feature combination that best distinguished LRRK2-associated PD from controls.

resultsBeat-to-beat and global HRV measures were significantly increased in LRRK2-associated PD patients compared with controls (e.g., deceleration capacity of heart rate: p = 0.006) and idiopathic PD patients (e.g., 8th standardized moment of the interbeat interval distribution: p = 0.0003), respectively. LRRK2-associated PD patients also showed significantly increased irregularity of heart rate dynamics, as quantified by Rényi entropy, when compared with controls (p = 0.002) and idiopathic PD patients (p = 0.0004). Ordinal pattern statistics permitted the identification of LRRK2-associated PD individuals with 93% sensitivity and 93% specificity. Consistent results were found in a subgroup of LRRK2-non-manifesting carriers when compared with controls.

conclusionsIncreased beat-to-beat HRV in LRRK2 G2019S mutation carriers compared with controls and idiopathic PD patients may indicate augmented cardiac autonomic cholinergic activity, suggesting early impairment of central vagal feedback loops in LRRK2-associated PD.

Indexed as

AgedFemaleHeart RateHumansLeucine-Rich Repeat Serine-Threonine Protein Kinase-2MaleMiddle AgedMutationParkinson DiseasePrimary DysautonomiasVagus NerveLeucine-Rich Repeat Serine-Threonine Protein Kinase-2LRRK2 protein, humanAutonomic dysfunctionDeceleration capacity of heart rateHeart rate variabilityLRRK2Parkinson’s diseaseRényi entropy

Identifiers

PMID31444591
OpenAlexW2969911928

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.