ReviewInsights into imaging2019
Diagnostic value of alternative techniques to gadolinium-based contrast agents in MR neuroimaging-a comprehensive overview.
Review in Insights into imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 71 citations in OpenAlex.
- Intracranial venous thrombosis imaging by anatomical location: an educational review with mimics and diagnostic pitfalls.Insights into imaging · 2026Article
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- Evaluating the Combined Effect of a Choline Kinase Inhibitor and Temozolomide Therapy in a Mouse Model of Glioblastoma UsingNMR in biomedicine · 2025Article
- Dynamic glucose enhanced imaging using direct water saturation.Magnetic resonance in medicine · 2025Article
- Translation of hyperpolarized [Npj imaging · 2025Article
- Role of Nanotechnology in Ischemic Stroke: Advancements in Targeted Therapies and Diagnostics for Enhanced Clinical Outcomes.Journal of functional biomaterials · 2025Review
- Gliomas Analysis via Multimodal MRI-Deep Learning Fusion: Technical Innovations in Segmentation, Molecular Subtyping, and Clinical Translation Pathways.Advances in medical education and practice · 2025Review
- A Study of Knowledge and Attitude of Medical Staff Towards 3D Black Blood MR Angio Methods in High-Resolution Magnetic Resonance Vessel Wall Imaging of Intracranial Arteries.Journal of multidisciplinary healthcare · 2025Article
- Environmental Sustainability and MRI: Challenges, Opportunities, and a Call for Action.Journal of magnetic resonance imaging : JMRI · 2024Review
- Diffusion-weighted imaging-based radiomics model using automatic machine learning to differentiate cerebral cystic metastases from brain abscesses.Journal of cancer research and clinical oncology · 2024Article
- Automatic Active Lesion Tracking in Multiple Sclerosis Using Unsupervised Machine Learning.Diagnostics (Basel, Switzerland) · 2024Article
- Low-dose GBCA administration for brain tumour dynamic contrast enhanced MRI: a feasibility study.Scientific reports · 2024Article
- Review
- [Predicting cerebral glioma enhancement pattern using a machine learning-based magnetic resonance imaging radiomics model].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024Article
- Super High Contrast USPIO-Enhanced Cerebrovascular Angiography Using Ultrashort Time-to-Echo MRI.International journal of biomedical imaging · 2024Article
- Multi-class glioma segmentation on real-world data with missing MRI sequences: comparison of three deep learning algorithms.Scientific reports · 2023Article
- Non-invasive assessment of normal and impaired iron homeostasis in the brain.Nature communications · 2023Article
- Article
- Arterial spin labeling clinical applications for brain tumors and tumor treatment complications: A comprehensive case-based review.The neuroradiology journal · 2023Review
- Reproducibility of 3 T APT-CEST in Healthy Volunteers and Patients With Brain Glioma.Journal of magnetic resonance imaging : JMRI · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gadolinium-based contrast agents (GBCAs) increase lesion detection and improve disease characterization for many cerebral pathologies investigated with MRI. These agents, introduced in the late 1980s, are in wide use today. However, some non-ionic linear GBCAs have been associated with the development of nephrogenic systemic fibrosis in patients with kidney failure. Gadolinium deposition has also been found in deep brain structures, although it is of unclear clinical relevance. Hence, new guidelines from the International Society for Magnetic Resonance in Medicine advocate cautious use of GBCA in clinical and research practice. Some linear GBCAs were restricted from use by the European Medicines Agency (EMA) in 2017.This review focuses on non-contrast-enhanced MRI techniques that can serve as alternatives for the use of GBCAs. Clinical studies on the diagnostic performance of non-contrast-enhanced as well as contrast-enhanced MRI methods, both well established and newly proposed, were included. Advantages and disadvantages together with the diagnostic performance of each method are detailed. Non-contrast-enhanced MRIs discussed in this review are arterial spin labeling (ASL), time of flight (TOF), phase contrast (PC), diffusion-weighted imaging (DWI), magnetic resonance spectroscopy (MRS), susceptibility weighted imaging (SWI), and amide proton transfer (APT) imaging.Ten common diseases were identified for which studies reported comparisons of non-contrast-enhanced and contrast-enhanced MRI. These specific diseases include primary brain tumors, metastases, abscess, multiple sclerosis, and vascular conditions such as aneurysm, arteriovenous malformation, arteriovenous fistula, intracranial carotid artery occlusive disease, hemorrhagic, and ischemic stroke.In general, non-contrast-enhanced techniques showed comparable diagnostic performance to contrast-enhanced MRI for specific diagnostic questions. However, some diagnoses still require contrast-enhanced imaging for a complete examination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.