Evidence map›Paper›PMID 31444563›Full record

ArticleHeart and vessels2020

Clinically feasible method for assessing leukocyte rheology in whole blood.

Riha Shimizu, Hirotsugu Fukuda, Yuji Kikuchi, Hirokazu Yanaka, Nobuhiro Hata, Masashi Yamazaki, Yuki Nakatani, Yuma Tamura, Seiko Yamakoshi, Atsuhiko Kawabe and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heart and vessels, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Riha ShimizuDepartment of Cardiac and Vascular Surgery, Dokkyo Medical University Nikko Medical Center, Nikko, Tochigi, Japan.
Hirotsugu FukudaDepartment of Cardiac and Vascular Surgery, Dokkyo Medical University Nikko Medical Center, Nikko, Tochigi, Japan.
Yuji KikuchiKikuchi Microtechnology Institute, Ryugasaki, Ibaraki, Japan.
Hirokazu YanakaDepartment of Clinical Laboratory, Dokkyo Medical University Nikko Medical Center, Nikko, Tochigi, Japan.
Nobuhiro HataNational Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan.
Masashi YamazakiNational Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan.
Yuki NakataniDepartment of Diabetes and Endocrinology, Dokkyo Medical University Nikko Medical Center, Nikko, Tochigi, Japan.
Yuma TamuraDepartment of Rehabilitation, Dokkyo Medical University Nikko Medical Center, Nikko, Tochigi, Japan.
Seiko YamakoshiDepartment of Rehabilitation, Dokkyo Medical University Nikko Medical Center, Nikko, Tochigi, Japan.
Atsuhiko KawabeDepartment of Cardiovascular Medicine and Nephrology, Dokkyo Medical University Nikko Medical Center, 632 Takatoku, Nikko, 321-2593, Tochigi, Japan.
Yasuto HorieDepartment of Cardiology, Dokkyo Medical University Nikko Medical Center, Nikko, Tochigi, Japan.
Hiroyuki SugimuraDepartment of Cardiology, Dokkyo Medical University Nikko Medical Center, Nikko, Tochigi, Japan.
Yasushi MatsushitaDepartment of Cardiac and Vascular Surgery, Dokkyo Medical University Nikko Medical Center, Nikko, Tochigi, Japan.
Takaaki NakamotoDepartment of Cardiology, Dokkyo Medical University Nikko Medical Center, Nikko, Tochigi, Japan.
Takanori YasuDepartment of Cardiovascular Medicine and Nephrology, Dokkyo Medical University Nikko Medical Center, 632 Takatoku, Nikko, 321-2593, Tochigi, Japan. tyasu@dokkyomed.ac.jp.

Funding

a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan 23500590a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan 26350581the Vehicle Racing Commemorative Foundation none
6 · The paper itself

Abstract

This study reports a novel method for assessment of leukocyte rheological activation with a new designed microchannel array chip to mimic the human microvascular network for microchannel array flow analysis (MCFAN). Study subjects were 79 healthy volunteers and 42 patients with type 2 diabetes mellitus (DM) and 36 patients with acute coronary syndrome (ACS). Using the anticoagulants heparin and ethylene-diamine-tetraacetic acid (EDTA)-2Na which inhibits platelets and leukocytes by chelating Ca

Indexed as

Cell AdhesionHemorheologyLeukocytesMicrofluidic Analytical TechniquesAcute Coronary SyndromeAdultAgedBiomarkersBlood Flow VelocityCase-Control StudiesDiabetes Mellitus, Type 2Feasibility StudiesFemaleHumansKineticsLab-On-A-Chip DevicesBiomarkersMPO protein, humanPeroxidaseAcute coronary syndromeDiabetes mellitusLeukocyteMicrocirculationRheology

Identifiers

PMID31444563
PMCPMC6981318

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.