Evidence map›Paper›PMID 31444414›Full record

ArticleOncogene2019

Long non-coding RNA NONHSAT101069 promotes epirubicin resistance, migration, and invasion of breast cancer cells through NONHSAT101069/miR-129-5p/Twist1 axis.

Na Yao, Yue Fu, Lie Chen, Zhao Liu, Jing He, Yichao Zhu, Tiansong Xia, Shui Wang

Abstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
8.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 131 citations in OpenAlex.

  1. Review
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  9. Review
  10. Article
  11. Breast Cancer Chemoresistance: Insights into the Regulatory Role of lncRNA.International journal of molecular sciences · 2023
    Review
  12. Article
  13. Landscape of NcRNAs involved in drug resistance of breast cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023
    Review
  14. Interplay between LncRNAs and microRNAs in Breast Cancer.International journal of molecular sciences · 2023
    Review
  15. Review
  16. Article
  17. Metformin and long non-coding RNAs in breast cancer.Journal of translational medicine · 2023
    Review
  18. Review
  19. Review
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Na Yao *Breast Disease Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, P. R. China.
Yue Fu *Department of General Surgery, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, 213000, Jiangsu Province, P. R. China.
Lie Chen *Breast Disease Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, P. R. China.
Zhao LiuDepartment of Thyroid & Breast Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 222100, Jiangsu Province, P. R. China.
Jing HeDepartment of Surgical Oncology, The Affiliated Hospital of Jiangnan University, Wuxi, 214000, Jiangsu Province, P. R. China.
Yichao ZhuDepartment of Physiology, Nanjing Medical University, Nanjing, 211166, Jiangsu Province, P. R. China. zhuyichao@njmu.edu.cn.ORCID http://orcid.org/0000-0003-3499-8510
Tiansong XiaBreast Disease Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, P. R. China. xiats@njmu.edu.cn.
Shui WangBreast Disease Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, P. R. China. ws0801@hotmail.com.
Jiangsu Province Hospital · CNChangzhou No.2 People's Hospital · CNCM Hospital · KRJiangnan University · CNNanjing Medical University · CNXuzhou Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug resistance, including epirubicin-based therapeutic resistance, is one of the major reasons responsible for the unfavorable prognosis of patients diagnosed with breast cancer (BC). Acquired chemoresistance and metastatic properties have been identified to be closely associated with the process of epithelial-mesenchymal transition (EMT). Recently, dysregulation of long non-coding RNAs (lncRNAs) have been increasingly reported to perform promotive or suppressive functions in chemoresistance and EMT process in multiple cancers. However, relevant novel lncRNA participating in epirubicin resistance and EMT and its underlying molecular mechanisms remain unknown in BC. Herein, we established the epirubicin-resistant breast cancer cell subline (MCF-7/ADR), which presented mesenchymal phenotype and increased metastatic potential. A panel of differentially expressed lncRNAs, including 268 upregulated and 49 downregulated lncRNAs, were identified by high-flux microarray investigation in MCF-7 and MCF-7/ADR cells. The novel lncRNA NONHSAT101069 was significantly overexpressed in BC specimens, BC cell lines, and epirubicin-resistant cell sublines. The knockdown of NONHSAT101069 significantly repressed, whereas overexpression of NONHSAT101069 promoted the epirubicin resistance, migration, invasion and EMT process of BC cells both in vitro and in vivo. Further mechanism-related researches uncovered that NONHSAT101069 functioned as a ceRNA (competing endogenous RNA) via sponging miR-129-5p. Twist1 was a direct downstream protein of NONHSAT101069/miR-129-5p axis in BC cells. To conclude, NONHSAT101069 was upregulated in BC tissues and promoted epirubicin resistance, migration and invasion of BC cells via regulation of NONHSAT101069/miR-129-5p/Twist1 axis, highlighting its potential as an oncogene and a therapeutic biomarker for BC.

Indexed as

Breast NeoplasmsCell MovementDrug Resistance, NeoplasmEpirubicinGene Expression Regulation, NeoplasticHumansMCF-7 CellsMicroRNAsNeoplasm InvasivenessNuclear ProteinsRNA, Long NoncodingTwist-Related Protein 1EpirubicinMicroRNAsMirn129 microRNA, humanNuclear ProteinsRNA, Long NoncodingTWIST1 protein, humanTwist-Related Protein 1

Identifiers

PMID31444414
OpenAlexW2969722757

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.