ArticleScientific reports2019
Botryane terpenoids produced by Nemania bipapillata, an endophytic fungus isolated from red alga Asparagopsis taxiformis - Falkenbergia stage.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 40 citations in OpenAlex.
- The effects of the secondary metabolites of the citrus endophytic fungus Nemania sp. LJZ-Y-11 on the citrus canker disease-causing pathogen Xanthomonas citri subsp. citri.BMC microbiology · 2025Article
- Endophytic xylariaceous fungi from rice in northern Thailand: discovery of novel species and new host records.MycoKeys · 2025Article
- Fungal Endophytes: Discovering What Lies within Some of Canada's Oldest and Most Resilient Grapevines.Journal of fungi (Basel, Switzerland) · 2024Article
- Anti-Alzheimer's Natural Products Derived from Plant Endophytic Fungi.Molecules (Basel, Switzerland) · 2023Review
- Sesquiterpenoids Specially Produced by Fungi: Structures, Biological Activities, Chemical and Biosynthesis (2015-2020).Journal of fungi (Basel, Switzerland) · 2021Review
- Volatile Constituents of Endophytic Fungi Isolated fromLife (Basel, Switzerland) · 2021Article
- New Techniques of Structure Elucidation for Sesquiterpenes.Progress in the chemistry of organic natural products · 2021Article
- Recent progress in biodiversity research on the Xylariales and their secondary metabolism.The Journal of antibiotics · 2021Review
- Endophytic fungus, Chaetomium globosum, associated with marine green alga, a new source of Chrysin.Scientific reports · 2020Article
- Arthrinins E-G, Three Botryane Sesquiterpenoids from the Plant Endophytic Fungus Arthrinium sp. HS66.Natural products and bioprospecting · 2020Article
- The Postbiotic Activity ofFrontiers in cellular and infection microbiology · 2020Article
- Article
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A chemical study of the EtOAc extract of Nemania bipapillata (AT-05), an endophytic fungus isolated from the marine red alga Asparagopsis taxiformis - Falkenbergia stage, led to the isolation of five new botryane sesquiterpenes, including the diastereomeric pair (+)-(2R,4S,5R,8S)-(1) and (+)-(2R,4R,5R,8S)-4-deacetyl-5-hydroxy-botryenalol (2), (+)-(2R,4S,5R,8R)-4-deacetyl-botryenalol (3), one pair of diastereomeric botryane norsesquiterpenes bearing an unprecedented degraded carbon skeleton, (+)-(2R,4R,8R)-(4) and (+)-(2R,4S,8S)-(5), which were named nemenonediol A and nemenonediol B, respectively, in addition to the known 4β-acetoxy-9β,10β,15α-trihydroxyprobotrydial (6). Their structures were elucidated using 1D and 2D NMR, HRESIMS and comparison with literature data of similar known compounds. The absolute configurations of 2, 3 and 4 were deduced by comparison of experimental and calculated electronic circular dichroism (ECD) spectra, while those of 1 and 5 were assigned from vibrational circular dichroism (VCD) data. Compound 4 weakly inhibited acetylcholinesterase, whereas compound 1 inhibited both acetylcholinesterase and butyrylcholinesterase. Compounds 1, 3, 5 and 6 were tested against two carcinoma cell lines (MCF-7 and HCT-116), but showed no significant citotoxicity at tested concentrations (IC
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