ArticleScientific reports2019
Disruptive effects of repeated stress on basolateral amygdala neurons and fear behavior across the estrous cycle in rats.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Functional specialization of mPFC-BLA and mPFC-NAc pathways in affective state representation.eLife · 2026Article
- Sex and dose-dependent effects of cannabidiol on cocaine consumption in mice.Translational psychiatry · 2026Article
- Impaired Synaptic Activity in the Basolateral Amygdala Is Associated With an Alcohol Use Disorder-Like Vulnerable Phenotype in Male Rats.Addiction biology · 2025Article
- Article
- Effects of repeated social stress on risk assessment behaviors and response to diazepam in the elevated plus maze in adult male rats.Behavioral neuroscience · 2025Article
- Elevated GABAergic neurotransmission prevents chronic intermittent ethanol induced hyperexcitability of intrinsic and extrinsic inputs to the ventral subiculum of female rats.Neurobiology of stress · 2025Article
- Sex differences in sensitivity to dopamine receptor manipulations of risk-based decision making in rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- A dual-pathway architecture enables chronic stress to disrupt agency and promote habit formation.bioRxiv : the preprint server for biology · 2024Article
- Elevated GABAergic neurotransmission prevents chronic intermittent ethanol induced hyperexcitability of intrinsic and extrinsic inputs to the ventral subiculum of female rats.Neurobiology of stress · 2024Article
- Article
- Sex-specific role of high-fat diet and stress on behavior, energy metabolism, and the ventromedial hypothalamus.Biology of sex differences · 2024Article
- Basolateral amygdala neuropeptide Y system modulates binge ethanol consumption.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Sex differences in avoidance behavior and cued threat memory dynamics in mice: Interactions between estrous cycle and genetic background.Hormones and behavior · 2023Article
- Circuit and Cell-Specific Contributions to Decision Making Involving Risk of Explicit Punishment in Male and Female Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Major gender differences in relations between life stressor frequency and gray matter in adolescence and emerging adulthood.Developmental psychology · 2023Article
- Involvement of brain cell phenotypes in stress-vulnerability and resilience.Frontiers in neuroscience · 2023Review
- Sex differences in fear responses: Neural circuits.Neuropharmacology · 2023Review
- Cocaine Exposure Increases Excitatory Synaptic Transmission and Intrinsic Excitability in the Basolateral Amygdala in Male and Female Rats and across the Estrous Cycle.Neuroendocrinology · 2023Article
- Riluzole prevents stress-induced spine plasticity in the hippocampus but mimics it in the amygdala.Neurobiology of stress · 2022Article
- Rodent models of stress and dendritic plasticity - Implications for psychopathology.Neurobiology of stress · 2022Article
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Authors and funding
4 authors.
Funding
Abstract
Stress is a precipitating factor in depression and anxiety disorders. Patients with these disorders often show amygdala abnormalities. The basolateral amygdala (BLA) is integral in mood and emotion, and is sensitive to stress. While much is known about effects of stress on BLA neuron activity and morphology in males, less is known in females. We tested whether repeated stress exerts distinct effects on BLA in vivo neuronal activity and morphology of Golgi-stained BLA neurons [lateral (LAT) and basal (BA) nuclei] in adult female rats. Repeated restraint stress increased BLA neuronal firing and caused hypertrophy of BLA neurons in males, while it decreased LAT and BA neuronal firing and caused hypotrophy of neurons in the LAT of females. BLA neuronal activity and function, such as fear conditioning, shifts across the estrous cycle. Repeated stress disrupted this pattern of BLA activity and fear expression over the estrous cycle. The disruptive effects of stress on the pattern of BLA function across estrous may produce behavior that is non-optimal for a specific phase of the estrous cycle. The contrasting effects of stress may contribute to sex differences in the effects of stress on mood and psychiatric disorders.
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