ReviewNature communications2019
Kinetic asymmetry allows macromolecular catalysts to drive an information ratchet.
Review in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
75 citing papers in PubMed, 208 citations in OpenAlex.
- Autonomous migration of a phosphate group along glycerol and inositol scaffolds driven by a phosphodiester reaction cycle.Nature chemistry · 2026Article
- Chiral catalysis-driven rotary molecular motors.Nature chemistry · 2026Article
- Recent Advancements in Information Ratchet Design.Molecules (Basel, Switzerland) · 2026Review
- Light-Driven Supramolecular Pumping by Changing Shape Complementarity.Journal of the American Chemical Society · 2026Article
- Solvent-Driven Modulation of Shuttling Dynamics in an Autonomous Chemically Fueled Information Ratchet.The journal of physical chemistry. B · 2025Article
- Light them up: photoresponsive imine-containing systems.Chemical science · 2025Review
- An information ratchet improves selectivity in molecular recognition under non-equilibrium conditions.Nature nanotechnology · 2025Article
- Article
- The molecular mechanism of ATP synthase constrains the evolutionary landscape of chemiosmosis.Biophysical journal · 2025Review
- Catalysis-driven Active Transport Across a Liquid Membrane.Angewandte Chemie (International ed. in English) · 2025Article
- A Catalysis-Driven Dual Molecular Motor.Journal of the American Chemical Society · 2025Article
- Structural Influence of the Chemical Fueling System on a Catalysis-Driven Rotary Molecular Motor.Journal of the American Chemical Society · 2025Article
- Computational Analysis of the Kinetic Requirements for Coupled Reaction Systems.Molecules (Basel, Switzerland) · 2025Article
- Transient transition from Stable to Dissipative Assemblies in Response to the Spatiotemporal Availability of a Chemical Fuel.Angewandte Chemie (International ed. in English) · 2025Article
- Power Strokes in Molecular Motors: Predictive, Irrelevant, or Somewhere in Between?Journal of the American Chemical Society · 2025Article
- Feedback driven autonomous cycles of assembly and disassembly from minimal building blocks.Nature communications · 2024Article
- Developmental assembly of multi-component polymer systems through interconnected synthetic gene networks in vitro.Nature communications · 2024Article
- Non-equilibrium self-assembly for living matter-like properties.Nature reviews. Chemistry · 2024Review
- Harnessing Maxwell's demon to establish a macroscale concentration gradient.Nature chemistry · 2024Article
- The sugar cube: Network control and emergence in stereoediting reactions.Science (New York, N.Y.) · 2024Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Molecular machines carry out their function by equilibrium mechanical motions in environments that are far from thermodynamic equilibrium. The mechanically equilibrated character of the trajectories of the macromolecule has allowed development of a powerful theoretical description, reminiscent of Onsager's trajectory thermodynamics, that is based on the principle of microscopic reversibility. Unlike the situation at thermodynamic equilibrium, kinetic parameters play a dominant role in determining steady-state concentrations away from thermodynamic equilibrium, and kinetic asymmetry provides a mechanism by which chemical free-energy released by catalysis can drive directed motion, molecular adaptation, and self-assembly. Several examples drawn from the recent literature, including a catenane-based chemically driven molecular rotor and a synthetic molecular assembler or pump, are discussed.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.