ArticleNature communications2019
Bacteria evoke alarm behaviour in zebrafish.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Correlated evolution of core skin structures in freshwater fishes and challenges to epidermal club cells as the material basis of alarm responses.Frontiers in zoology · 2026Article
- Integrated Sensory and Immune Cell Organization in the Lip Skin of the Goldfish (Animals : an open access journal from MDPI · 2026Article
- Comparative transcriptomics of lateral hypothalamic cell types reveals conserved growth hormone-tachykinin dynamics in feeding.Molecular metabolism · 2025Article
- The evolution of cavefish odor perception shifts fish response from avoidance to approach when exposed to alarm and death odors.bioRxiv : the preprint server for biology · 2025Article
- The axillary lymphoid organ is an external, experimentally accessible immune organ in the zebrafish.The Journal of experimental medicine · 2025Article
- Gasocrine hypothesis - a potential supplement to cell theory.Acta biochimica Polonica · 2025Article
- Mesenchymal Stem Cells Carrying Viral Fusogenic Protein p14 to Treat Solid Tumors by Inducing Cell-Cell Fusion and Immune Activation.Research (Washington, D.C.) · 2025Article
- Serotonergic modulation of vigilance states in zebrafish and mice.Nature communications · 2024Article
- Acquired predator recognition via epidermal alarm cues but not dietary alarm cues by isolated pupfish.Royal Society open science · 2023Article
- A single-cell resolution gene expression atlas of the larval zebrafish brain.Science advances · 2023Article
- Neuromasts and Olfactory Organs of Zebrafish Larvae Represent Possible Sites of SARS-CoV-2 Pseudovirus Host Cell Entry.Journal of virology · 2022Article
- Using zebrafish to understand reciprocal interactions between the nervous and immune systems and the microbial world.Journal of neuroinflammation · 2022Review
- Larval Zebrafish as a Model for Mechanistic Discovery in Mental Health.Frontiers in molecular neuroscience · 2022Review
- The habenula clock influences response to a stressor.Neurobiology of stress · 2021Article
- Epidermal Club Cells in Fishes: A Case for Ecoimmunological Analysis.International journal of molecular sciences · 2021Review
- Odor hedonics coding in the vertebrate olfactory bulb.Cell and tissue research · 2021Review
- Olfactory Rod Cells: A Rare Cell Type in the Larval Zebrafish Olfactory Epithelium With a Large Actin-Rich Apical Projection.Frontiers in physiology · 2021Article
- Metabolic and behavioral features of acute hyperpurinergia and the maternal immune activation mouse model of autism spectrum disorder.PloS one · 2021Article
- A chemical circular communication network at the nanoscale.Chemical science · 2020Article
- Stimulus-specific behavioral responses of zebrafish to a large range of odors exhibit individual variability.BMC biology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 4 countries.
Funding
Abstract
When injured, fish release an alarm substance (Schreckstoff) that elicits fear in members of their shoal. Although Schreckstoff has been proposed to be produced by club cells in the skin, several observations indicate that these giant cells function primarily in immunity. Previous data indicate that the alarm substance can be isolated from mucus. Here we show that mucus, as well as bacteria, are transported from the external surface into club cells, by cytoplasmic transfer or invasion of cells, including neutrophils. The presence of bacteria inside club cells raises the possibility that the alarm substance may contain a bacterial component. Indeed, lysate from a zebrafish Staphylococcus isolate is sufficient to elicit alarm behaviour, acting in concert with a substance from fish. These results suggest that Schreckstoff, which allows one individual to unwittingly change the emotional state of the surrounding population, derives from two kingdoms and is associated with processes that protect the host from bacteria.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.