ArticleNature communications2019
Integration of cortical population signals for visual perception.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Cortical Response to Acute Implantation of the Utah Optrode Array in Macaque Cortex.Advanced healthcare materials · 2026Article
- Unsupervised learning of temporal regularities in visual cortical populations.Nature communications · 2025Article
- Optogenetic Manipulation of Covert Attention in the Nonhuman Primate.Journal of cognitive neuroscience · 2025Article
- An optrode array for spatiotemporally-precise large-scale optogenetic stimulation of deep cortical layers in non-human primates.Communications biology · 2024Article
- Mechanisms underlying reshuffling of visual responses by optogenetic stimulation in mice and monkeys.Neuron · 2023Article
- Rapid compensatory plasticity revealed by dynamic correlated activity in monkeys in vivo.Nature neuroscience · 2023Article
- Endogenous fluctuations in cortical state selectively enhance different modes of sensory processing in human temporal lobe.Nature communications · 2023Article
- Behavioral optogenetics in nonhuman primates; a psychological perspective.Current research in neurobiology · 2023Review
- Optogenetic stimulation of the primary visual cortex drives activity in the visual association cortex.Current research in neurobiology · 2023Article
- Head-mounted optical imaging and optogenetic stimulation system for use in behaving primates.Cell reports methods · 2022Article
- The Spatial Reach of Neuronal Coherence and Spike-Field Coupling across the Human Neocortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Brain state limits propagation of neural signals in laminar cortical circuits.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Chronic bisphenol A exposure triggers visual perception dysfunction through impoverished neuronal coding ability in the primary visual cortex.Archives of toxicology · 2022Article
- Similar neural and perceptual masking effects of low-power optogenetic stimulation in primate V1.eLife · 2022Article
- Vision Restoration by Optogenetic Therapy and Developments Toward Sonogenetic Therapy.Translational vision science & technology · 2022Article
- Understanding them to understand ourselves: The importance of NHP research for translational neuroscience.Current research in neurobiology · 2022Article
- Intensity patterns at the peaks of brain activity in fMRI and PET are highly correlated with neural models of spatial integration.The European journal of neuroscience · 2021Article
- Article
- An Open Resource for Non-human Primate Optogenetics.Neuron · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Visual stimuli evoke heterogeneous responses across nearby neural populations. These signals must be locally integrated to contribute to perception, but the principles underlying this process are unknown. Here, we exploit the systematic organization of orientation preference in macaque primary visual cortex (V1) and perform causal manipulations to examine the limits of signal integration. Optogenetic stimulation and visual stimuli are used to simultaneously drive two neural populations with overlapping receptive fields. We report that optogenetic stimulation raises firing rates uniformly across conditions, but improves the detection of visual stimuli only when activating cells that are preferentially-tuned to the visual stimulus. Further, we show that changes in correlated variability are exclusively present when the optogenetically and visually-activated populations are functionally-proximal, suggesting that correlation changes represent a hallmark of signal integration. Our results demonstrate that information from functionally-proximal neurons is pooled for perception, but functionally-distal signals remain independent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.