Evidence map›Paper›PMID 31444232›Full record

ArticleMolecular cancer research : MCR2019

Intron 1-Mediated Regulation of

Nathan M Jameson, Jianhui Ma, Jorge Benitez, Alejandro Izurieta, Jee Yun Han, Robert Mendez, Alison Parisian, Frank Furnari

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cancer research : MCR, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
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  13. PHLPPing the Script: Emerging Roles of PHLPP Phosphatases in Cell Signaling.Annual review of pharmacology and toxicology · 2021
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 3 countries.

Nathan M JamesonLudwig Cancer Research, San Diego Branch, University of California at San Diego, La Jolla, California.ORCID 0000-0002-5253-2004
Jianhui MaLudwig Cancer Research, San Diego Branch, University of California at San Diego, La Jolla, California.ORCID 0000-0002-9374-2673
Jorge BenitezLudwig Cancer Research, San Diego Branch, University of California at San Diego, La Jolla, California.
Alejandro IzurietaLudwig Cancer Research, San Diego Branch, University of California at San Diego, La Jolla, California.
Jee Yun HanCenter for Epigenomics, University of California at San Diego, La Jolla, California.
Robert MendezCenter for Epigenomics, University of California at San Diego, La Jolla, California.
Alison ParisianLudwig Cancer Research, San Diego Branch, University of California at San Diego, La Jolla, California.ORCID 0000-0001-5706-0571
Frank FurnariLudwig Cancer Research, San Diego Branch, University of California at San Diego, La Jolla, California. ffurnari@ucsd.edu.
University of California San Diego · USAcadia Pharmaceuticals (United States) · US

Funding

Training Program in Basic Clinical GeneticsT32GM008666 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HAMILTON, BRUCE A · 1998 to 2021
$8.6M
Predoctoral and Postdoctoral Training in Cancer Cell BiologyT32CA067754 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEAN Y.J. WANG · 1995 to 2026
$6.5M
Genotypic Interactions in Brain Cancer HeterogeneityR01NS080939 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FURNARI, FRANK · 2012 to 2022
$3.5M
Genotypic Interactions in Brain Cancer HeterogeneityR56NS080939 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FURNARI, FRANK · 2023 to 2023
$537k
NCI NIH HHS T32 CA067754NIGMS NIH HHS T32 GM008666NINDS NIH HHS R01 NS080939NINDS NIH HHS R56 NS080939
6 · The paper itself

Abstract

The epidermal growth factor receptor (EGFR) is overexpressed in numerous solid tumors and is the subject of extensive therapeutic efforts. Much of the research on EGFR is focused on protein dynamics and downstream signaling; however, few studies have explored its transcriptional regulation. Here, we identified two enhancers (CE1 and CE2) present within the first intron of the

Indexed as

Gene Expression Regulation, NeoplasticBromodomain Containing ProteinsCell Line, TumorChromatinEnhancer Elements, GeneticEpigenesis, GeneticErbB ReceptorsGenes, ReporterGlioblastomaHumansIntronsPromoter Regions, GeneticProteinsSignal TransductionSquamous Cell Carcinoma of Head and NeckTranscription Factor AP-1bromodomain and extra-terminal domain protein, humanBromodomain Containing ProteinsChromatinEGFR protein, humanErbB ReceptorsProteinsTranscription Factor AP-1

Identifiers

PMID31444232
PMCPMC6825583
OpenAlexW2969762476

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.