Evidence map›Paper›PMID 31444227›Full record

ArticleeNeuro

The Role of BTBD9 in Striatum and Restless Legs Syndrome.

Shangru Lyu, Hong Xing, Mark P DeAndrade, Yuning Liu, Pablo D Perez, Fumiaki Yokoi, Marcelo Febo, Arthur S Walters, Yuqing Li

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Putative Animal Models of Restless Legs Syndrome: A Systematic Review and Evaluation of Their Face and Construct Validity.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Shangru LyuNorman Fixel Institute for Neurological Diseases, Department of Neurology, College of Medicine, University of Florida Gainesville, FL 32610.
Hong XingNorman Fixel Institute for Neurological Diseases, Department of Neurology, College of Medicine, University of Florida Gainesville, FL 32610.
Mark P DeAndradeNorman Fixel Institute for Neurological Diseases, Department of Neurology, College of Medicine, University of Florida Gainesville, FL 32610.
Yuning LiuNorman Fixel Institute for Neurological Diseases, Department of Neurology, College of Medicine, University of Florida Gainesville, FL 32610.
Pablo D PerezDepartment of Psychiatry, College of Medicine, University of Florida Gainesville, FL 32610.
Fumiaki YokoiNorman Fixel Institute for Neurological Diseases, Department of Neurology, College of Medicine, University of Florida Gainesville, FL 32610.
Marcelo FeboDepartment of Psychiatry, College of Medicine, University of Florida Gainesville, FL 32610.
Arthur S WaltersDivision of Sleep Medicine, Vanderbilt University Medical Center, Nashville, TN.
Yuqing LiNorman Fixel Institute for Neurological Diseases, Department of Neurology, College of Medicine, University of Florida Gainesville, FL 32610 yuqing.li@neurology.ufl.edu.ORCID 0000-0003-1211-5529
University of Florida · USVanderbilt University Medical Center · US

Funding

Restless Legs Syndrome: Pathophysiology using Btbd9 Conditional Knockout MiceR01NS082244 · NINDS · UNIVERSITY OF FLORIDA · PI LI, YUQING · 2014 to 2018
$1.6M
Pathophysiology and Animal Model of Restless Legs Syndrome (RLS): Btbd9 Null MicR21NS065273 · NINDS · UNIVERSITY OF FLORIDA · PI LI, YUQING · 2009 to 2010
$401k
NINDS NIH HHS R01 NS082244NINDS NIH HHS R21 NS065273
6 · The paper itself

Abstract

Restless legs syndrome (RLS) is a sensory-motor neurological disorder characterized by uncomfortable sensations in the extremities, generally at night, which is often relieved by movements. Genome-wide association studies (GWAS) have identified mutations in

Indexed as

AnimalsCorpus StriatumFemaleMaleMembrane PotentialsMiceMice, KnockoutNerve Tissue ProteinsOrgan Culture TechniquesRestless Legs SyndromeBtbd9 protein, mouseNerve Tissue ProteinsBTBD9cholinergic interneuronmedium spiny neuronRestless legs syndromesleepstriatum

Identifiers

PMID31444227
PMCPMC6787346
OpenAlexW2969772569

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.