ArticleBiological psychiatry2019
White Matter Microstructure and Its Relation to Longitudinal Measures of Depressive Symptoms in Mid- and Late Life.
Article in Biological psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Multimorbidity patterns and mental health in late life: a systematic review of longitudinal studies.European geriatric medicine · 2026Pooled it
- Early life adversity and white matter microstructural organization-a systematic review.Brain imaging and behavior · 2025Pooled it
- Diffusion Tensor Imaging to Analyze White Matter Tract Abnormalities in Major Psychiatric Disorders.Avicenna journal of medicine · 2025Article
- Genome-wide analysis identifies novel shared loci between depression and white matter microstructure.Molecular psychiatry · 2025Article
- Longitudinal associations between white matter integrity, early life adversities, and treatment response following cognitive-behavioral therapy in depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Deep learning-based image reconstruction benefits diffusion tensor imaging for assessing severity of depression.Frontiers in neuroscience · 2025Article
- Effects of educational attainment on comorbidity of pain and depression in Chinese older adults.Heliyon · 2024Article
- Associations of depression and perceived physical fatigability with white matter integrity in older adults.Psychiatry research. Neuroimaging · 2024Article
- Research status and global trends of late-life depression from 2004 to 2023: bibliometric analysis.Frontiers in aging neuroscience · 2024Article
- Brain multi-contrast, multi-atlas segmentation of diffusion tensor imaging and ensemble learning automatically diagnose late-life depression.Scientific reports · 2023Article
- Pathway-Based Polygenic Risk Scores for Schizophrenia and Associations With Reported Psychotic-like Experiences and Neuroimaging Phenotypes in the UK Biobank.Biological psychiatry global open science · 2023Article
- The heterogeneity of late-life depression and its pathobiology: a brain network dysfunction disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2023Review
- The impact of loneliness and social adaptation on depressive symptoms: Behavioral and brain measures evidence from a brain health perspective.Frontiers in psychology · 2023Article
- The enigma of vascular depression in old age: a critical update.Journal of neural transmission (Vienna, Austria : 1996) · 2022Review
- Positive coping style reduction in elderly end-stage renal disease patients: mediating role of white matter mean diffusivity.Neuroradiology · 2022Article
- Elevated homocysteine levels, white matter abnormalities and cognitive impairment in patients with late-life depression.Frontiers in aging neuroscience · 2022Article
- Brain structural associations with depression in a large early adolescent sample (the ABCD study®).EClinicalMedicine · 2021Article
- Brain-based mechanisms of late-life depression: Implications for novel interventions.Seminars in cell & developmental biology · 2021Review
- White matter abnormalities in adults with bipolar disorder type-II and unipolar depression.Scientific reports · 2021Article
- Digital sleep measures and white matter health in the Framingham Heart Study.Exploration of medicine · 2021Article
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6 authors at 1 institution in 1 country.
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Abstract
backgroundStudies of white matter microstructure in depression typically show alterations in individuals with depression, but they are frequently limited by small sample sizes and the absence of longitudinal measures of depressive symptoms. Depressive symptoms are dynamic, however, and understanding the neurobiology of different trajectories could have important clinical implications.
methodsWe examined associations between current and longitudinal measures of depressive symptoms and white matter microstructure (fractional anisotropy and mean diffusivity [MD]) in the UK Biobank Imaging Study. Depressive symptoms were assessed on two to four occasions over 5.9 to 10.7 years (n = 18,959 individuals on at least two occasions, n = 4444 on four occasions), from which we derived four measures of depressive symptomatology: cross-sectional measure at the time of scan and three longitudinal measures, namely trajectory and mean and intrasubject variance over time.
resultsDecreased white matter microstructure in the anterior thalamic radiation demonstrated significant associations across all four measures of depressive symptoms (MD: βs = .020-.029, p
conclusionsThese findings indicate shared and differential neurobiological associations with severity, course, and intrasubject variability of depressive symptoms. This enriches our understanding of the neurobiology underlying dynamic features of the disorder.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.