Evidence map›Paper›PMID 31443912›Full record

ReviewTrends in neurosciences2019

Neural Substrates of Inhibitory Control Maturation in Adolescence.

Christos Constantinidis, Beatriz Luna

Abstract readReview
In one paragraph

Review in Trends in neurosciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  13. Trajectories of Response Inhibition Development in Adolescence.bioRxiv : the preprint server for biology · 2026
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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Christos ConstantinidisDepartment of Neurobiology and Anatomy, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA. Electronic address: cconstan@wakehealth.edu.
Beatriz LunaDepartments of Psychiatry, Pediatrics, and Psychology, University of Pittsburgh, and The Center for the Neural Basis of Cognition, Pittsburgh, PA 15213, USA. Electronic address: lunab@upmc.edu.

Funding

Refinement of Brain Mechanisms Underlying the Developmental Stabilization from Adolescent to Adult Neurocognitive ProcessingR01MH067924 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BEATRIZ LUNA · 2004 to 2026
$14.0M
Reward Processing in AdolescenceR01MH080243 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LUNA, BEATRIZ · 2008 to 2019
$5.5M
Adolescent striatal neurophysiological maturation underlying the transition to adult stabilization of behaviorR37MH080243 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BEATRIZ LUNA · 2022 to 2026
$3.4M
Neurophysiology of Working Memory Maturation in AdolescenceR01MH116675 · NIMH · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CONSTANTINIDIS, CHRISTOS, WHITLOW, CHRISTOPHER T · 2018 to 2022
$2.4M
Neurophysiology of cognitive development and response inhibitionR01MH117996 · NIMH · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CONSTANTINIDIS, CHRISTOS · 2018 to 2022
$2.1M
NIMH NIH HHS R01 MH067924NIMH NIH HHS R01 MH080243NIMH NIH HHS R01 MH116675NIMH NIH HHS R01 MH117996NIMH NIH HHS R37 MH080243
6 · The paper itself

Abstract

Inhibitory control matures through adolescence and into early adulthood, impacting decision-making. Impairments in inhibitory control are associated with various psychopathologies, many of which emerge during adolescence. In this review, we examine the neural basis of developmental improvements in inhibitory control by integrating findings from humans and non-human primates, identifying the structural and functional specialization of executive brain systems that mediates cognitive maturation. Behavioral manifestations of response inhibition suggest that adolescents are capable of producing adult level responses on occasion, but lack the ability to engage systems mediating response inhibition in a consistent fashion. Maturation is associated with changes in structural anatomy as well as local and systems-level connectivity. Functional changes revealed by neuroimaging and neurophysiology indicate that maturation of inhibitory control is achieved through improvements in response preparation, error processing, and planned responses.

Indexed as

Synaptic TransmissionAdolescentBrainBrain MappingCognitionExecutive FunctionHumansMagnetic Resonance Imagingantisaccadedevelopmentexecutive functionfMRIneurophysiologyprefrontalresponse inhibition

Identifiers

PMID31443912
PMCPMC6721973

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.