Evidence map›Paper›PMID 31443895›Full record

ArticleThe Journal of pediatrics2019

Vascular Health of Children Conceived via In Vitro Fertilization.

Wendy Y Zhang, Elif Seda Selamet Tierney, Angela C Chen, Albee Y Ling, Raquel R Fleischmann, Valerie L Baker

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Pooled it
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  3. Review
  4. Effect of Perinatal and Maternal Factors on Blood Pressure and Adiposity at Age 3.Journal of clinical hypertension (Greenwich, Conn.) · 2026
    Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Wendy Y ZhangStanford University School of Medicine, Stanford, CA. Electronic address: wendyz@stanford.edu.
Elif Seda Selamet TierneyDivision of Pediatric Cardiology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA.
Angela C ChenDivision of Pediatric Cardiology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA.
Albee Y LingQuantitative Sciences Unit, Stanford University School of Medicine, Stanford, CA.
Raquel R FleischmannStanford University School of Medicine, Stanford, CA.
Valerie L BakerDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA; Johns Hopkins University School of Medicine, Department of Gynecology and Obstetrics, Division of Reproductive Endocrinology and Infertility, Baltimore, MD.
Stanford University · USJohns Hopkins University · USStanford Medicine · US

Funding

Stanford Center for Clinical & Translational Education and Research (Spectrum)UL1TR003142 · NCATS · STANFORD UNIVERSITY · PI O'HARA, RUTH M · 2019 to 2023
$45.0M
Spectrum Stanford Center for clinical and Translational Research and EducationUL1TR001085 · NCATS · STANFORD UNIVERSITY · PI CULLEN, MARK RICHARD, GREENBERG, HARRY BERNARD · 2013 to 2017
$37.1M
NCATS NIH HHS UL1 TR001085NCATS NIH HHS UL1 TR003142
6 · The paper itself

Abstract

objectiveTo evaluate whether in vitro fertilization (IVF) has an effect on the cardiovascular health of offspring. STUDY

designThis was a cross-sectional pilot study. We performed vascular health assessment for 17 children aged 10-14 years who were conceived via IVF with autologous oocytes at Stanford University. Carotid artery ultrasound evaluated intima-media thickness and stiffness, carotid-femoral pulse wave velocity determined segmental arterial stiffness, and endothelial pulse amplitude testing assessed endothelial function. We compared IVF offspring with control adolescents assessed in the same laboratory, with all comparisons adjusted for age, sex, and race/ethnicity.

resultsAll participants had normal body mass index and blood pressure. Compared with controls, IVF children had thicker common carotid artery intima-media thickness (0.44 ± 0.03 mm vs 0.38 ± 0.03 mm; P < .01), higher elastic modulus (395.29 ± 185.33 mm Hg vs 242.79 ± 37.69 mm Hg; P = .01), higher β

conclusionIn an assessment of endothelial function and arterial properties of children conceived via IVF, we found that children conceived via IVF seem to have evidence of abnormal vascular health. Further studies with larger sample size and long-term follow-up are warranted.

Indexed as

AdolescentCardiovascular DiseasesCarotid Intima-Media ThicknessCase-Control StudiesChildCross-Sectional StudiesFemaleFertilization in VitroHumansMalePilot ProjectsPulse Wave AnalysisRisk FactorsVascular Stiffnessbeta-stiffnesscarotid intima-media thicknesselastic modulusendothelial pulse amplitude testingpulse wave velocity

Identifiers

PMID31443895
PMCPMC6815705
OpenAlexW2969724649

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.