Evidence map›Paper›PMID 31443880›Full record

ReviewChild and adolescent psychiatric clinics of North America2019

The Neurobiology of Eating Disorders.

Guido K W Frank, Megan E Shott, Marisa C DeGuzman

2 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Child and adolescent psychiatric clinics of North America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 70 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06000774 narecruitingnot on this mapstarted 2023, after this paper: background citation

Ketogenic Diet in Eating Disorders to Target Metabolism and Normalize Persistent Eating Disorder Psychopathology

TypeinterventionalSponsorUniversity of California, San DiegoRan2023 to 2027Enrolled20ConditionsAnorexia Nervosa in Remission, Bulimia Nervosa, Anorexia NervosaArmsTherapeutic Ketogenic Diet
NCT06605027 nawithdrawnnot on this mapstarted 2027, after this paper: background citation

Therapeutic Ketogenic Diet to Treat Anorexia Nervosa-Specific Cognitions and Behaviors - Currently Ill Individuals in PHP Level of Care and Comparison With Standard of Care

TypeinterventionalSponsorUniversity of California, San DiegoRan2027 to 2028Enrolled0ConditionsAnorexia NervosaArmsTherapeutic Ketogenic Diet
3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Childhood maltreatment and the risk of eating disorders: a meta-analysis of observational studies.Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2025
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Review
  7. Time to Address Eating Disorder Risk Among Medical Students.Behavioral sciences (Basel, Switzerland) · 2026
    Review
  8. Review
  9. Recovery From Anorexia Nervosa: A Concept Analysis.Journal of advanced nursing · 2026
    Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. When Is the Right Time to End Family Therapy for Anorexia Nervosa (FT-AN)?: A Qualitative Study of Young People's Experiences.European eating disorders review : the journal of the Eating Disorders Association · 2026
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Guido K W FrankUniversity of California San Diego, UCSD Eating Disorder Center, 4510 Executive Dr #315, San Diego, CA 92121, USA; Rady Children's Hospital San Diego, San Diego, CA, USA. Electronic address: Guido.Frank@ucdenver.edu.
Megan E ShottUniversity of California San Diego, UCSD Eating Disorder Center, 4510 Executive Dr #315, San Diego, CA 92121, USA; Rady Children's Hospital San Diego, San Diego, CA, USA.
Marisa C DeGuzmanDepartment of Psychiatry, University of Colorado Anschutz Medical Campus, School of Medicine, Children's Hospital Colorado, Gary Pavilion A036/B-130, 13123 East 16th Avenue, Aurora, CO 80045, USA.

Funding

Neuroscience Training GrantT32NS099042 · NINDS · UNIVERSITY OF COLORADO DENVER · PI Nidia Calero, GIDON S FELSEN · 2016 to 2026
$2.1M
Taste reward circuits and prediction error define eating disorder psychopathologyR01MH103436 · NIMH · UNIVERSITY OF COLORADO DENVER · PI STODDARD, JOEL JOHNSON · 2014 to 2018
$2.0M
Brain Reward Circuits and Computational Modeling in Adolescent Anorexia NervosaR01MH096777 · NIMH · UNIVERSITY OF COLORADO DENVER · PI FRANK, GUIDO KW · 2012 to 2016
$1.5M
NIMH NIH HHS R01 MH096777NIMH NIH HHS R01 MH103436NINDS NIH HHS T32 NS099042
6 · The paper itself

Abstract

Eating disorders are severe psychiatric illnesses with a typical age of onset in adolescence. Brain research in youth and young adults may help us identify specific neurobiology that contributes to onset and maintenance of those disorders. This article provides a state-of-the-art review of our current understanding of the neurobiology of anorexia nervosa and bulimia nervosa. This includes brain structure and function studies to understand food restriction, binge-eating or purging behaviors, cognitive and emotional factors, as well as interoception. Binge-eating disorder and avoidant restrictive food intake disorder are also discussed, but the literature is still very small.

Indexed as

Nerve NetNeurobiologyAdolescentAnorexia NervosaBinge-Eating DisorderBrainBulimia NervosaChildFeeding and Eating DisordersHumansMagnetic Resonance ImagingYoung AdultAnorexia nervosaBrainBulimia nervosaEating disorderImagingNeurobiology

Identifiers

PMID31443880
PMCPMC6709695

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.