ArticleLipids in health and disease2019
Lipid profiling of suction blister fluid: comparison of lipids in interstitial fluid and plasma.
Article in Lipids in health and disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 49 citations in OpenAlex.
- The detection of cardiovascular biomarkers in dermal interstitial fluid - a step to real-time monitoring.Frontiers in cardiovascular medicine · 2026Review
- A microneedle device for rapid dermal interstitial fluid sampling.Science advances · 2025Article
- Advances in microneedles for transdermal diagnostics and sensing applications.Mikrochimica acta · 2024Review
- Microneedle Sensors for Point-of-Care Diagnostics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- ZFP750 affects the cutaneous barrier through regulating lipid metabolism.Science advances · 2023Article
- Microneedle-based interstitial fluid extraction for drug analysis: Advances, challenges, and prospects.Journal of pharmaceutical analysis · 2023Review
- Fluid-based wearable sensors: a turning point in personalized healthcare.Turkish journal of chemistry · 2023Article
- Local burn wound environment versus systemic response: Comparison of proteins and metabolites.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2022Article
- Closing the loop for patients with Parkinson disease: where are we?Nature reviews. Neurology · 2022Review
- Temperature acclimation of net photosynthesis and its underlying component processes in four tropical tree species.Tree physiology · 2022Article
- Reference materials for MS-based untargeted metabolomics and lipidomics: a review by the metabolomics quality assurance and quality control consortium (mQACC).Metabolomics : Official journal of the Metabolomic Society · 2022Review
- Microneedle-based devices for point-of-care infectious disease diagnostics.Acta pharmaceutica Sinica. B · 2021Review
- Enhanced extraction of skin interstitial fluid using a 3D printed device enabling tilted microneedle penetration.Scientific reports · 2021Article
- Sphingolipidomics of serum in extremely preterm infants: Association between low sphingosine-1-phosphate levels and severe retinopathy of prematurity.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2021Article
- The Impact of Olive Oil Compounds on the Metabolic Reprogramming of Cutaneous Melanoma Cell Models.Molecules (Basel, Switzerland) · 2021Article
- Minimally Invasive Biospecimen Collection for Exposome Research in Children's Health.Current environmental health reports · 2020Review
- Exploring the Lipidome: Current Lipid Extraction Techniques for Mass Spectrometry Analysis.Metabolites · 2020Review
- Inflammatory Markers in Suction Blister Fluid: A Comparative Study Between Interstitial Fluid and Plasma.Frontiers in immunology · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundRecent technical advances in the extraction of dermal interstitial fluid (ISF) have stimulated interest in using this rather unexploited biofluid as an alternative to blood for detection and prediction of disease. However, knowledge about the presence of useful biomarkers for health monitoring in ISF is still limited. In this study, we characterized the lipidome of human suction blister fluid (SBF) as a surrogate for pure ISF and compared it to that of plasma.
methodsPlasma and SBF samples were obtained from 18 healthy human volunteers after an overnight fast. Total lipids were extracted and analyzed by liquid chromatography-tandem mass spectrometry. One hundred ninety-three lipid species covering 10 complex lipid classes were detected and quantified in both plasma and SBF using multiple reaction monitoring. A fraction of the lipid extract was subjected to alkaline transesterification and fatty acid methyl esters were analyzed by gas chromatography-mass spectrometry.
resultsThe total concentration of lipids in SBF was 17% of the plasma lipid concentration. The molar fraction of lipid species within lipid classes, as well as total fatty acids, showed a generally high correlation between plasma and SBF. However, SBF had larger fractions of lysophospholipids and diglycerides relative to plasma, and consequently less diacylphospholipids and triglycerides. Principal component analysis revealed that the interindividual variation in SBF lipid profiles was considerably larger than the within-subject variation between plasma and SBF.
conclusionsPlasma and SBF lipid profiles show high correlation and SBF could be used interchangeably with blood for the analysis of major lipids used in health monitoring.
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