ArticleBMC pregnancy and childbirth2019
The REVAMP study: research exploring various aspects and mechanisms in preeclampsia: study protocol.
Article in BMC pregnancy and childbirth, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Epigenetic landscape of placental tissue in preeclampsia: a systematic review of DNA methylation profiles.BMC pregnancy and childbirth · 2025Pooled it
- Elevated placental inflammation as a mediator of adverse outcomes in gestational diabetes mellitus.Molecular and cellular biochemistry · 2026Article
- Angiogenic Markers in Gestational Diabetes and their Association with Placental Dimensions.Molecular and cellular biochemistry · 2025Article
- Longitudinal assessment of maternal micronutrients (folate and vitamin BEuropean journal of clinical nutrition · 2025Article
- Maternal angiogenic factor disruptions prior to clinical diagnosis of preeclampsia: insights from the REVAMP study.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Longitudinal Assessment of Oxidative Stress Markers in Women with Preeclampsia.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- Observational
- Longitudinal Assessment of Calcium and Magnesium Levels in Women with Preeclampsia.Biological trace element research · 2023Observational
- Determinants and neonatal outcomes of preeclampsia among women living with and without HIV at a tertiary hospital in Zambia: a review of medical records.The Pan African medical journal · 2022Review
- Gestational weight gain in the REVAMP pregnancy cohort in Western India: Comparison with international and national references.Frontiers in medicine · 2022Article
- Unravelling the potential of angiogenic factors for the early prediction of preeclampsia.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Review
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Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundPreeclampsia is a major cause of maternal, fetal and neonatal morbidity and mortality, particularly in developing countries. Considering the burden of preeclampsia and its associated complications, it is important to understand the underlying risk factors and mechanisms involved in its etiology. There is considerable interest in the potential for dietary long chain polyunsaturated fatty acids (LCPUFA) as a therapeutic intervention to prevent preeclampsia, as they are involved in angiogenesis, oxidative stress, and inflammatory pathways.
methodsThe REVAMP study (Research Exploring Various Aspects and Mechanisms in Preeclampsia) follows a cohort of pregnant women from early pregnancy until delivery to examine longitudinally the associations of maternal LCPUFA with clinical outcome in preeclampsia. A multisite centre for advanced research was established and pregnant women coming to Bharati hospital and Gupte hospital, Pune, India for their first antenatal visit are recruited and followed up at 11-14 weeks, 18-22 weeks, 26-28 weeks, and at delivery. Their personal, obstetric, clinical, and family history are recorded. Anthropometric measures (height, weight), food frequency questionnaire (FFQ), physical activity, socioeconomic status, fetal ultrasonography, and color Doppler measures are recorded at different time points across gestation. Maternal blood at all time points, cord blood, and placenta at delivery are collected, processed and stored at - 80 °C. The children's anthropometry is assessed serially up to the age of 2 years, when their neurodevelopmental scores will be assessed. DISCUSSION: This study will help in early identification of pregnant women who are at risk of developing preeclampsia. The prospective design of the study for the first time will establish the role of LCPUFA in understanding the underlying biochemical and molecular mechanisms involved in preeclampsia and their association with developmental programming in children.
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