SynthesisCritical care (London, England)2019
Effect of different methods of cooling for targeted temperature management on outcome after cardiac arrest: a systematic review and meta-analysis.
Synthesis in Critical care (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Impact of fever on the outcome non-anoxic acute brain injury patients: a systematic review and meta-analysis.Critical care (London, England) · 2024Pooled it
- [Targeted temperature management after cardiac arrest : What is new?]Der Anaesthesist · 2022Pooled it
- Optimal Time of Collapse to Return of Spontaneous Circulation to Apply Targeted Temperature Management for Cardiac Arrest: A Bayesian Network Meta-Analysis.Frontiers in cardiovascular medicine · 2021Pooled it
- Intravascular vs. surface cooling in out-of-hospital cardiac arrest patients receiving hypothermia after hospital arrival: a post hoc analysis of the TTM2 trial.Intensive care medicine · 2025Trial
- Hypothermia versus normothermia in patients with cardiac arrest and shockable rhythm: a secondary analysis of the TTM-2 study.Critical care (London, England) · 2024Trial
- Comparing intravascular and surface cooling methods: a critical look at outcomes for out-of-hospital cardiac arrest patients.Intensive care medicine · 2025Article
- From surface to core: does better cooling make a difference after cardiac arrest?Intensive care medicine · 2025Article
- Management of Patients With Cardiac Arrest Requiring Interfacility Transport: A Scientific Statement From the American Heart Association.Circulation · 2024Review
- Commentary on Minimizing Shivering During Targeted Normothermia.Neurocritical care · 2023Article
- The Identification of Subsequent Events Following Out-of-Hospital Cardiac Arrests with Targeted Temperature Management.Acta Cardiologica Sinica · 2023Article
- A Commentary on the Effect of Targeted Temperature Management in Patients Resuscitated from Cardiac Arrest.Therapeutic hypothermia and temperature management · 2023Article
- Out-of-hospital cardiac arrest complicated by hyperthermia.Resuscitation plus · 2022Article
- Targeted temperature management evolving over time-A local process analysis.Acta anaesthesiologica Scandinavica · 2022Article
- Target temperature management versus normothermia without temperature feedback systems for out-of-hospital cardiac arrest survivors.The Journal of international medical research · 2022Article
- Cost-Effectiveness Analysis of Intravascular Targeted Temperature Management after Cardiac Arrest in England.PharmacoEconomics - open · 2022Article
- Artificial neural network-boosted Cardiac Arrest Survival Post-Resuscitation In-hospital (CASPRI) score accurately predicts outcome in cardiac arrest patients treated with targeted temperature management.Scientific reports · 2022Observational
- Impact of cooling method on the outcome of initial shockable or non-shockable out of hospital cardiac arrest patients receiving target temperature management: a nationwide multicentre cohort study.Annals of intensive care · 2021Article
- Cardiac arrest: An interdisciplinary scoping review of the literature from 2019.Resuscitation plus · 2020Article
- Resuscitating the Globally Ischemic Brain: TTM and Beyond.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020Review
- High Quality Targeted Temperature Management (TTM) After Cardiac Arrest.Critical care (London, England) · 2020Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough targeted temperature management (TTM) is recommended in comatose survivors after cardiac arrest (CA), the optimal method to deliver TTM remains unknown. We performed a meta-analysis to evaluate the effects of different TTM methods on survival and neurological outcome after adult CA.
methodsWe searched on the MEDLINE/PubMed database until 22 February 2019 for comparative studies that evaluated at least two different TTM methods in CA patients. Data were extracted independently by two authors. We used the Newcastle-Ottawa Scale and a modified Cochrane ROB tools for assessing the risk of bias of each study. The primary outcome was the occurrence of unfavorable neurological outcome (UO); secondary outcomes included overall mortality.
resultsOur search identified 6886 studies; 22 studies (n = 8027 patients) were included in the final analysis. When compared to surface cooling, core methods showed a lower probability of UO (OR 0.85 [95% CIs 0.75-0.96]; p = 0.008) but not mortality (OR 0.88 [95% CIs 0.62-1.25]; p = 0.21). No significant heterogeneity was observed among studies. However, these effects were observed in the analyses of non-RCTs. A significant lower probability of both UO and mortality were observed when invasive TTM methods were compared to non-invasive TTM methods and when temperature feedback devices (TFD) were compared to non-TFD methods. These results were significant particularly in non-RCTs.
conclusionsAlthough existing literature is mostly based on retrospective or prospective studies, specific TTM methods (i.e., core, invasive, and with TFD) were associated with a lower probability of poor neurological outcome when compared to other methods in adult CA survivors (CRD42019111021).
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