ArticleRespiratory research2019
Critical combination of initial markers for predicting refractory Mycoplasma pneumoniae pneumonia in children: a case control study.
Article in Respiratory research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed, 87 citations in OpenAlex.
- Application of Clinical Indicators in the Early Prediction of RefractoryClinical pediatrics · 2026Article
- Clinical factors associated with extrapulmonary complications in children with macrolide-resistantTranslational pediatrics · 2026Article
- Risk factors and construction of prediction model for plastic bronchitis in children withTranslational pediatrics · 2026Article
- East Asia as a sentinel: risk-stratified corticosteroid therapy for paediatric macrolide-resistantEuropean respiratory review : an official journal of the European Respiratory Society · 2026Review
- Dysregulated myeloid-T cell immunity in refractory Mycoplasma pneumoniae pneumonia: high inflammation meets T cell suppression.BMC microbiology · 2026Article
- Article
- Risk factors and prediction models for bronchitis obliterans after severe Mycoplasma pneumoniae pneumonia with plastic bronchitis in children.Pakistan journal of medical sciences · 2026Article
- Role of Serum Inflammatory Biomarkers in Risk Stratification of Hospitalized Children with Macrolide-Non-ResponsiveChildren (Basel, Switzerland) · 2026Article
- [Development of a predictive model for severeZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Article
- Association analysis of Mycoplasma pneumoniae 23S rRNA gene mutation with refractory Mycoplasma pneumoniae pneumonia in children.PloS one · 2026Article
- Early identification of refractoryFrontiers in medicine · 2026Article
- The Role of NLR and Ferritin Levels as Biomarkers for Corticosteroid Dosage in Children with RefractoryJournal of inflammation research · 2026Article
- Screening of early predictive serum biomarkers and construction of a combined predictive model for refractoryFrontiers in pediatrics · 2026Article
- Exploring Clinical Characteristics and Risk Factors ofJournal of inflammation research · 2026Article
- Clinical characteristics and cytokine profiles for early prediction of severeFrontiers in pediatrics · 2026Article
- Development and validation of a predictive nomogram for early detection of necrotizing pneumonia in children with refractoryFrontiers in pediatrics · 2026Article
- Early risk stratification of adverse progression in pediatricFrontiers in medicine · 2026Article
- Development and validation of a nomogram for predicting necrotizing pneumonia in children with refractory Mycoplasma pneumoniae pneumonia.Italian journal of pediatrics · 2025Article
- Impact of body mass index on clinical outcomes in pediatric patients with mycoplasma pneumoniae pneumonia: a retrospective cohort study.Translational pediatrics · 2025Article
- Neutrophils are involved in the development and outcomes of plastic bronchitis associated with Mycoplasma pneumoniae pneumonia.Respiratory research · 2025Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is unclear whether the responses of refractory and common Mycoplasma pneumoniae (MP) pneumonia to macrolides differ. Hence, this study aimed to identify biomarkers that may be used to distinguish refractory and common pneumonias caused by MP in children at hospital admission.
methodsThe study included 123 children divided into five groups according to infection agent and treatment protocol: Group I included those with MP infection without documented viral infection, treated with only macrolides; Group II included those with MP infection without documented viral infection, treated with a combination of macrolides and methylprednisolone; Group III included those with MP infection and documented viral infection, treated with only macrolides; Group IV included those with viral pneumonia without documented MP infection; Group V was the control group composed of admitted children without MP or a documented viral infection. These five groups were further subdivided into Groups A (including Groups I, III, IV, and V) and B (Group II) according to the responses to macrolide treatment. Concentrations of cytokines interleukin 6, interleukin 17, interleukin 18, and tumor necrosis factor-α, and lactate dehydrogenase, and ferritin of all children were evaluated, and these levels were compared among the groups. Statistical comparisons were made using Kruskal Wallis test and Mann-Whitney U test.
resultsSerum lactate dehydrogenase, interleukin 18, and ferritin concentrations were significantly higher in Group II than in Groups I, III, IV, and V and were significantly higher in Group B than in Group A. When the serum lactate dehydrogenase concentration was 350 IU/L or higher, the sensitivity and specificity for diagnosing refractory MP pneumonia were 73 and 80%, respectively. When the interleukin 18 level was 360 pg/mL or higher, the sensitivity and specificity for diagnosing refractory MP pneumonia were 93 and 70%, respectively. When the ferritin level was 230 pg/mL or higher, the sensitivity and specificity for diagnosing refractory MP pneumonia were 67 and 67%, respectively.
conclusionThese results suggest that serum lactate dehydrogenase, interleukin 18, and ferritin constitute the critical combination of biomarkers useful for predicting refractory MP pneumonia in children at hospital admission.
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