ArticleBMC evolutionary biology2019
Somatic maintenance impacts the evolution of mutation rate.
Article in BMC evolutionary biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
6 citing papers in PubMed.
- The adaptive state determines the impact of mutations on evolving populations.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The Elephant and the Spandrel.Evolution, medicine, and public health · 2025Article
- Review
- Neutrophil dynamics and inflammaging in acute ischemic stroke: A transcriptomic review.Frontiers in aging neuroscience · 2022Review
- The Longevity of Colonies of Fungus-Growing Termites and the Stability of the Symbiosis.Insects · 2020Review
- The three dimensions of somatic evolution: Integrating the role of genetic damage, life-history traits, and aging in carcinogenesis.Evolutionary applications · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
backgroundThe evolution of multi-cellular animals has produced a conspicuous trend toward increased body size. This trend has introduced at least two novel problems: an expected elevated risk of somatic disorders, such as cancer, and declining evolvability due to generally reduced population size, lower reproduction rate and extended generation time. Low population size is widely recognized to explain the high mutation rates in animals by limiting the presumed universally negative selection acting on mutation rates.
resultsHere, we present evidence from stochastic modeling that the direction and strength of selection acting on mutation rates is highly dependent on the evolution of somatic maintenance, and thus longevity, which modulates the cost of somatic mutations.
conclusionsWe argue that the impact of the evolution of longevity on mutation rates may have been critical in facilitating animal evolution.
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Registered trials
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